Stop study.
- Conditions
- haemophilia, prophylaxis, adherence, bleeds, arthropathy.hemofilie, profylaxe, therapietrouw, bloedingen, arthropathie.
- Registration Number
- NL-OMON25201
- Lead Sponsor
- niversity Medical Center Utrecht (UMC Utrecht)
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 90
Inclusion Criteria
1. Severe haemophilia A (factor VIII < 0.01 IU/ml);
2. Born between January 1st 1970 and January 1st 1988;
Exclusion Criteria
1. History of inhibitory activity of more than 5 BU at any time or less than 5 BU for more than one year;
2. Inadequate access to treatment during the first years of life (i.e. no access to unlimited replacement therapy during the first 4 years of life, e.g. in case of immigration);
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Joint status according to Haemophilia Joint Health Score (HJHS) and Pettersson score;<br /><br>2. Annual number of joint bleeds;<br /><br>3. Figure 8 walk test.
- Secondary Outcome Measures
Name Time Method 1. Clotting factor consumption;<br /><br>2. Orthopaedic surgery;<br /><br>3. Hospital admissions in the third decade of life;<br /><br>4. Major soft tissue bleeds.