Comparison of Prophylaxis and On-demand Treatment in Children With Moderate to Severe Hemophilia A
Not Applicable
Completed
- Conditions
- Hemophilia AProphylaxis
- Interventions
- Other: prophylaxis treatment, on demand treatment
- Registration Number
- NCT02362581
- Lead Sponsor
- Chulalongkorn University
- Brief Summary
Comparison of prophylaxis and on-demand treatment in children with moderate to severe hemophilia A.
This study determines to compare the efficacy of prophylaxis and on-demand treatment in moderate to severe hemophilia A children in King Chulalongkorn Memorial Hospital, Bangkok, Thailand
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 15
Inclusion Criteria
- Age between 6 months to 18 years
- Diagnosis severe and moderate hemophilia A
Exclusion Criteria
- platelet < 100,000/mm3
- No factor VIII inhibitor
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description On demand treatment, prophylaxis treatment prophylaxis treatment, on demand treatment On demand treatment arm:Patients received factorVIII concentrate(Hemofil M) when they had bleeding episodes. Prophylaxis arm: patients received factorVIII concentrate (Hemofil M) 30-35 unit/kg once a week
- Primary Outcome Measures
Name Time Method Number of admission days one year Number of bleeding episodes require treatment one year number of school days lost one year
- Secondary Outcome Measures
Name Time Method Joint scores one year Amount of Facter VIII concentration used one year Quality of life score one year
Trial Locations
- Locations (1)
pediatric Hemato-oncology department, King Chulalongkorn Memorial Hospital
🇹🇭Pratumwan, Bangkok, Thailand