Study " COFLORES ":Imaging of Coronary Reserve Without Tracers
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Myocardial Perfusion
- Sponsor
- Assistance Publique Hopitaux De Marseille
- Enrollment
- 53
- Locations
- 1
- Primary Endpoint
- Myocardial perfusion
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
Myocardial perfusion is a major parameter characterizing the status of capillary circulation of the myocardium. Its quantification is possible using Magnetic Resonance Imaging (MRI) during the 1st pass of a contrast agent through the capillary system. This technique is radiation-free, but it is difficult to repeat measurements during a single exam. Also, a number of patients suffering from cardiac disease cannot receive contrast agent injections. The investigators have developed a totally non-invasive approach for quantifying myocardial perfusion. It is based on the magnetic labeling of arterial spins. Flowing into the capillaries (Arterial spin labeling, ASL).
Goal : The major goal of this research protocol is to validate a totally non-invasive method of myocardial blood flow quantification using MRI without contrast agent injection
Investigators
Eligibility Criteria
Inclusion Criteria
- •People having no heart disease or treatment referred to cardiology
- •People having no cons -indications to MRI
- •People having no cons -indications to gadolinium ;
- •People not wearing implantable devices
- •People not wearing metallic foreign bodies or risk (eg . Business of steel, etc .. )
- •People having no cardiovascular risk factor
- •Person subject to the social security scheme
- •Nobody agreeing to participate in the study and who signed the informed consent
Exclusion Criteria
- •Refusal to go spontaneous or MRI because of claustrophobia important
- •Trouble rhythm making MRI uninterpretable
Outcomes
Primary Outcomes
Myocardial perfusion
Time Frame: 1day
MRI based on the magnetic labeling of arterial spins
Secondary Outcomes
- the myocardial sodium(1day)
- the myocardial energetic status(1day)