Observational Study on Monitoring NSAID-Induced Gastropathy in Patients Using Magnetically-Controlled Capsule Gastroscopy
- Conditions
- NSAID-Associated Gastropathy
- Registration Number
- NCT06027060
- Lead Sponsor
- Shanghai Jiao Tong University School of Medicine
- Brief Summary
The objective of this study is to observe gastric mucosal injuries in NSAID and non-NSAID users with magnetically-controlled capsule gastroscopy, and explore the effects of NSAIDs on gastric mucosal damage.
- Detailed Description
Non-steroidal anti-inflammatory drugs are widely used in all kinds of people in China. A major limitation to their use is the adverse effects they cause on the gastrointestinal tract, including the formation of stomach lesions, ulcers due to stress reactions, and damage to the healing of gastric ulcers. The purpose of this prospective, single-center study was to monitor the gastric mucosal injury in patients with and without NSAIDs using magnetron capsule gastroscopy, and to explore the effect of NSaids on gastric mucosal injury.
For people taking NSAIDs, it is necessary to regularly detect gastric mucosal damage, and timely intervention treatment is required if relevant lesions are found, and the medication plan is adjusted. Magnetron capsule gastroscope has the advantages of comfort, safety, no anesthesia, no risk of cross infection, etc. It is highly accepted by the population, and is a beneficial supplement to traditional gastroscopy, so that some people with absolute or relative contraindications of traditional gastroscopy can get timely endoscopy, and can be diagnosed and treated early.
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 180
- Planned magnetically-controlled capsule gastroscopy
- NSAID use >3 months or no NSAID use
- Informed consent
- No surgical conditions or refuses abdominal surgery (Once the capsule is stuck it cannot be removed surgically);
- Cardiac pacemakers (except MRI-compatible ones);
- Electronic implants or metal foreign bodies;
- Pregnant women;
- Known or suspected GI obstruction, stenosis, fistula;
- Dysphagia.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Gastric diseases detected 1 day Gastric diseases detected
- Secondary Outcome Measures
Name Time Method Effects of NSAID dosage on gastric injury 1 day Effects of NSAID dosage on gastric injury
Gastric mucosal injury by Lanza score 1 day Gastric mucosal injury by Lanza score
Gastric transit time 1 day Gastric transit time
Effects of NSAID duration on gastric injury 1 day Effects of NSAID duration on gastric injury
Gastric cleanliness 1 day Gastric cleanliness
Trial Locations
- Locations (1)
Departments of Gastroenterology and Clinical Laboratory, Shanghai Renji Hospital, Shanghai Jiaotong University School of Medicine
🇨🇳Shanghai, China