Non-steroidal Anti-inflammatory Drugs (NSAIDs) and Risk of Acute Kidney Injury in Patients With Heart Failure

• Conditions: Heart Failure

• Registration Number: NCT02642081
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

The purpose of this study is to evaluate whether non-steroidal anti-inflammatory drugs (NSAIDs) were associated with acute kidney injury (AKI) in patients with heart failure. In addition, the investigators would like to assess the risk of admission for acute decompensated heart failure following exposure to NSAIDs within 30 days.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2015-12-17
• Study First Submitted QC: 2015-12-24
• Study First Posted: 2015-12-30
• Status Verified: 2016-01
• Study Start: 2016-01
• Last Update Submitted: 2016-01-06
• Last Update Posted: 2016-01-07
• Primary Completion: 2016-06
• Study Completion: 2016-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change from baseline in serum creatinine at 1 month	Baseline and 1 month	We collect not only patient's baseline serum creatinine level (defined as the median value of the previous-six-months serum creatinine), but also serum creatinine level on the detecting day (defined as the most recent day from index date we detecting the serum creatinine). Acute kidney injury is defined as the absolute increase in the serum creatinine concentration of ≥0.3 mg/dL from baseline; or a percentage increase in the serum creatinine concentration of ≥50 percent.

Secondary Outcome Measures

Name	Time	Method
Admission for acute decompensated heart failure	1 month after exposure to NSAIDs

Trial Locations

Locations (1)

National Taiwan University Hospital; 🇨🇳 Taipei, Taiwan