Influence of Non-steroidal Anti-inflammatory Drugs (NSAID) on Muscle Regeneration

Not Applicable

Completed

• Conditions: Muscle Damage
• Interventions: Drug: placebo; Drug: NSAID

• Registration Number: NCT00832663
• Lead Sponsor: Bispebjerg Hospital

Brief Summary

The purpose of this study is to determine the influence of non-steroidal anti-inflammatory drugs (NSAIDs) on muscle regeneration.

The investigators' hypothesis is that ingestion of NSAID will delay or impair muscle regeneration.

Detailed Description

The model employed to induce muscle damage is electrical stimulation. Muscle biopsies will be examined to follow the response of satellite cells and muscle regeneration. Study participants will be randomly assigned to a placebo or NSAID group in a double-blinded manner.

Study Timeline

• Study First Submitted: 2009-01-29
• Study First Submitted QC: 2009-01-29
• Study First Posted: 2009-01-30
• Study Start: 2009-04
• Primary Completion: 2009-12
• Study Completion: 2009-12
• Status Verified: 2010-03
• Last Update Submitted: 2010-03-15
• Last Update Posted: 2010-03-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 32

Inclusion Criteria

• male
• healthy
• does not exercise regularly

Exclusion Criteria

• displays contraindications for taking NSAID
• well-trained

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Placebo	placebo	receive placebo
NSAID	NSAID	receive NSAID

Primary Outcome Measures

Name	Time	Method
Muscle regeneration	1 month

Secondary Outcome Measures

Name	Time	Method
Muscle strength	1 month

Trial Locations

Locations (1)

Bispebjerg Hospital; 🇩🇰 Copenhagen, NV, Denmark