Clinical, experimental, and genetic studies on the etiology of central serous chorioretinopathy

Recruiting

• Conditions: central serous chorioretinopathy; 10047060

• Registration Number: NL-OMON42212
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 825

Inclusion Criteria

All participants will be aged above 18 years.;1) Genetic analysis and ophthalmological examination in a CSC patient cohort, and in known families with CSC.
* Sporadic CSC: CSC patients who visit or visited the outpatient clinic of the Department of Ophthalmology in either the Leiden University Medical Center or the Rotterdam Eye Hospital.
* Familial CSC: CSC patients, who have at least one family member in whom CSC has been detected. ;2) Analysis of serum complement activity in CSC patients and in a healthy control group.
* CSC patients who visit the outpatient clinic of the Department of Ophthalmology in the Leiden University Medical Center. Per patient a control will be recruited. For example, the husband or wife of each CSC patient who visits the outpatient clinic of the department of Ophthalmology.;3) Endocrinological analysis of cortisol and testosterone exposure and sensitivity in CSC patients and in controls.
* CSC patients who visit the outpatient clinic of the Department of Ophthalmology in the Leiden University Medical Center will be referred to the outpatient clinic of the Department of Endocrinology. ;4) Analysis of the retinal phenotype and choroidal thickness in patients with Cushing*s syndrome, Conn*s syndrome, patients who receive solumedrol (a corticosteroid) during acute rejection of a renal transplant, or post renal transplantation patients who receive corticosteroids.
* Patients with Cushing*s syndrome or Conn*s syndrome who visit or visited the outpatient clinic of the Department of Endocrinology and are willing to take part in this study.
* Patients receiving solumedrol during acute rejection of a renal transplant, or post renal transplantation patients who receive corticosteroids, who visit or visited the outpatient clinic of the Department of Nephrology and are willing to take part in this study.

Exclusion Criteria

For our study no exclusion criteria are applicable.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified