KCT0003181
Active, Not Recruiting
N/A
Exploration of pathophysiologic mechanism of cerebrovascular disease as a risk factor of dementia using blood-brain barrier imaging and genomics
ConditionsDiseases of the nervous system
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Diseases of the nervous system
- Sponsor
- Konkuk University Medical Center
- Enrollment
- 88
- Status
- Active, Not Recruiting
- Last Updated
- 5 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\)Patients with Dementia due to AD or MCI due to AD (intermediate to high biomarker probability) according to the NIA\-AA diagnostic guidelines (2011\).Informed consent before participation in the study
- •2\)In case of patient with dementia, Clinical dementia rating (CDR) of 0\.5 or 1, which means a mild stage of dementia
- •3\)Age of 45\-80
- •4\)Informed consent understood, signed and patient agrees to all follow\-up visits.
Exclusion Criteria
- •1\) Contraindications for scanning (e.g. brain surgery, cardiac pacemaker, metal implants, claustrophobia, large body tattoos)
- •2\) Contraindications for contrast agent Gadovist (renal failure) as determined by the estimated Glomular Filtration Rate eGFR \< 30 mL/min.
- •3\) Major vascular disorders (e.g. stroke, heart disease)
- •4\) Psychiatric or neurological disorders: Major depression (\< 12 months); history of schizophrenia; bipolar disorder; psychotic disorder NOS or treatment for a psychotic disorder (\< 12 months); cognitive impairment due to alcohol abuse; epilepsy; Parkinson's disease; MS; brain surgery; brain trauma; electroshock therapy; kidney dialysis; Meniere's disease; and brain infections.
- •5\) Structural abnormalities of the brain
- •6\) Cognitive impairment due to alcohol/drug abuse
- •7\) Absence of reliable informant (for patient groups)
Outcomes
Primary Outcomes
Not specified
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