Exploration of pathophysiologic mechanism of cerebrovascular disease as a risk factor of dementia using blood-brain barrier imaging and genomics

Konkuk University Medical Center0 个研究点目标入组 88 人开始时间: 待定最近更新: 2021年1月28日

适应症

试验速览

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•1)Patients with Dementia due to AD or MCI due to AD (intermediate to high biomarker probability) according to the NIA-AA diagnostic guidelines (2011).Informed consent before participation in the study
•2)In case of patient with dementia, Clinical dementia rating (CDR) of 0.5 or 1, which means a mild stage of dementia
•3)Age of 45-80
•4)Informed consent understood, signed and patient agrees to all follow-up visits.

•1) Contraindications for scanning (e.g. brain surgery, cardiac pacemaker, metal implants, claustrophobia, large body tattoos)
•2) Contraindications for contrast agent Gadovist (renal failure) as determined by the estimated Glomular Filtration Rate eGFR < 30 mL/min.
•3) Major vascular disorders (e.g. stroke, heart disease)
•4) Psychiatric or neurological disorders: Major depression (< 12 months); history of schizophrenia; bipolar disorder; psychotic disorder NOS or treatment for a psychotic disorder (< 12 months); cognitive impairment due to alcohol abuse; epilepsy; Parkinson's disease; MS; brain surgery; brain trauma; electroshock therapy; kidney dialysis; Meniere's disease; and brain infections.
•5) Structural abnormalities of the brain
•6) Cognitive impairment due to alcohol/drug abuse
•7) Absence of reliable informant (for patient groups)

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