EFFECTS OF SGLT2 INHIBITORS ON LEFT VENTRICULAR DIMENSIONS AND FUNCTION IN MYOCARDIAL INFARCTION PATIENTS WITH LEFT VENTRICULAR DYSFUNCTIO

Department of Cardiology Kasturba Medical College and Hospital Manipal0 个研究点目标入组 0 人开始时间: 待定最近更新: 2021年11月24日

试验速览

暂无简介。

•1. Extensive MI
•2. LVEF <50%
•3. Diagnosed with T2DM, defined as:
•Prior documentation of type 2 diabetes AND/OR
•Treatment with anti-hyperglycemic medications and/or
•diet AND/OR
•ADA criteria: fasting >126 mg/dl (7.0 mmol/L) or
•HbA1C >=6.5% or 2-h plasma glucose>=200 mg/dl (11.1
•mmol/L) during an oral glucose tolerance test, or a
•random plasma glucose >= 200 mg/dL (11.1 mmol/L) in
•patients with classic symptoms of hyperglycemia or
•hyperglycemic crisis.
•4. Creatinine clearance of 30 ml or more per minute.
•5. Patients on optimal antidiabetic therapy of oral hypoglycemic
•agents including SGLT2 inhibitors and/or insulin.
•6. On optimal therapy post MI including dual antiplatelets, statins,beta blockers/ARBâ??s/ACE inhibitors, aldosterone antagonists
•and/or diuretics, if tolerated.

•1. Severe infection
•2. Serious liver or renal functional failure (estimated glomerular filtration rate [eGFR] <30 mL/min/1.73 m2)
•3. Alcohol dependency or use of illicit drugs
•4. Pregnant or breastfeeding, possibly pregnant, or planning to become pregnant in the study period (female patients only)
•5. Dehydration (abnormal hematocrit [Ht] and blood urea nitrogen, symptoms of dehydration);urinary tract or genital infection
•6. History of hypersensitivity to the study drugs
•7. Severe ketosis, diabetic coma or precoma
•8. Ongoing or past history of pancreatitis

发起方

Department of Cardiology Kasturba Medical College and Hospital Manipal