Effects of Childhood Trauma on Stress Reactivity: an MR study - MRS and Childhood Trauma

Psychiatrie0 个研究点目标入组 120 人开始时间: 待定最近更新: 2024年4月23日

适应症

试验速览

暂无简介。

•General exclusion criteria:
•- Incapability of giving informed consent
•- Lack of fluency in the Dutch language or speech impairments
•- Irregular sleep/wake rhythm (e.g., regular nightshifts or cross timeline travel).
•- Use of medication which might influence the stress response, such as psychotropics, beta blockers, ACE inhibitors and any hormonal treatment.
•- Major medical history including history of closed or open head injury.
•- Acute minor medical illness within the three weeks prior to testing
•- History of any psychiatric, neurological or endocrine disorder including claustrophobia and alcohol abuse or dependence
•- Self-reported current smoking in the last 2 weeks
•- Self-reported current or past drug use in the last 2 weeks
•- Ferrous objects in or around the body according to default checklist present at 7T scanner (version defined by METC protocol 07-235: *MRI development for 7T (and lower field strengths)* ;Acute exclusion criteria on 2nd and 3rd visit:
•- Any acute inflammatory disease
•- Physical exertion within the last 2 hours
•- Drink other than water or any food within the last 2 hours
•- Any alcohol use in the last 24 hours
•- Positive urine screen on the presence of amphetamines (including MDMA), barbiturates, cannabinoids, benzodiazepines, cocaine and opiates)

发起方

Psychiatrie