Controlled Donors After Circulatory Death and Brain Death: a Multicenter Study of Transfusion, One-year Graft Survival and Mortality. Cohort Study,

Completed

• Conditions: Liver Transplant

• Registration Number: NCT04945135
• Lead Sponsor: Hospital Clinic of Barcelona

Brief Summary

RBC requirement ein DBD and DCD liver transplants

Detailed Description

Background: Controlled donation after cardiac circulatory death (cDCD) is accepted to expand the donor pool for liver transplantation (LT). However, transfusion requirements and perioperative outcomes should be elucidated. The aims of this multicentre study are to assess the red blood cell (RBC) transfusions, one-year graft and patient survival after LT with cDCD compared to donors after brain dead (DBD).

Methods: 591 LT patients conducted in ten centers during 2019 were reviewed. Thromboelastometry was used to manage coagulation and blood product transfusion in all centres. Normothermic regional perfusion was the standard technique for organ recovery.

Study Timeline

• Study Start: 2019-06-01
• Primary Completion: 2020-01-01
• Status Verified: 2021-06
• Study Completion: 2021-06-25
• Study First Submitted: 2021-06-25
• Study First Submitted QC: 2021-06-25
• Last Update Submitted: 2021-06-25
• Study First Posted: 2021-06-30
• Last Update Posted: 2021-06-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 591

Inclusion Criteria

• patients undergoing LT

Exclusion Criteria

• acute liver failure

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
RBC transfusion	intraoperative

Trial Locations

Locations (2)

Hospital Universitari de Bellvitge; 🇪🇸 L'Hospitalet de Llobregat, Barcelona, Spain

Hospital de Cruces; 🇪🇸 Bilbao, Spain