Effect of a Short Nap During the Night Shift of Healthcare Workers on Endothelial Function

Not Applicable

Recruiting

• Conditions: Healthy Volonteers
• Interventions: Behavioral: Control condition (30-min rest); Behavioral: On-duty Nap; Device: EndoPAT; Device: Popmeter®; Device: Panasonic EW3109; Device: ECG Holter; Biological: Fasting blood sample; Other: Pichot fatigue scale; Other: French version of the Recovery Needs Scale (BRD); Other: The Short-Form 36 (SF-36); Other: Pittsburgh Sleep Quality Index (PSQI); Other: Epworth questionnaire; Other: The Karolinska Sleepiness Scale; Device: Actimeter

• Registration Number: NCT05955729
• Lead Sponsor: Centre Hospitalier Universitaire de Saint Etienne

Brief Summary

Night shift work is well known to cause health disruption in short and long term. It has been reported that among healthcare workers, nurses slept less than 6 h/24h. Consequences of such short sleep duration has been associated to long term issues such as endothelial dysfunction associated with cardiovascular diseases, arterial hypertension and type 2 diabetes. Countermeasures such as nap at work has potential effects on reducing the prevalence of cardiovascular diseases. However, to our knowledge, no studies have objectively investigated the effects of napping on endothelial function in a longitudinal design. Therefore, this study aims to investigate the effect of a 30 minutes on-duty nap during night work for 12 weeks on caregivers endothelial dysfunction.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2023-06-23
• Study First Submitted QC: 2023-07-19
• Study First Posted: 2023-07-21
• Study Start: 2024-02-19
• Status Verified: 2025-02
• Last Update Submitted: 2025-02-11
• Last Update Posted: 2025-02-12
• Primary Completion: 2025-12
• Study Completion: 2025-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• Being a paramedical caregiverr (nurse or care assistant) at Saint-Etienne University Hospital
• Be aAged between 18 and 65
• Working at least 80% of a full-time equivalent post
• Working 12-hour shifts (day/night) in continuous care services
• Being affiliated or entitled under a social security scheme
• Havinge received informed information about the study and have co-signed, with the investigator, a consent to participate in the study

Exclusion Criteria

• Have made a tTrans meridian journey in the last month prior to the study
• Have a mMedically diagnosed sleep disorder such asof the hypersomnia or insomnia type
• Have a diagnosed and treated mental pathology
• Usually take a nap in the workplace in a quiet room
• Be pregnant or breastfeeding
• Have medically diagnosed neurovascular or neuromuscular pathologies

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Nap group	EndoPAT	The experimental group will be allocated to do a 30-min on-duty nap during night work, in a dedicated room between 1 am and 4 am.
Nap group	Panasonic EW3109	The experimental group will be allocated to do a 30-min on-duty nap during night work, in a dedicated room between 1 am and 4 am.
Nap group	Fasting blood sample	The experimental group will be allocated to do a 30-min on-duty nap during night work, in a dedicated room between 1 am and 4 am.
Nap group	French version of the Recovery Needs Scale (BRD)	The experimental group will be allocated to do a 30-min on-duty nap during night work, in a dedicated room between 1 am and 4 am.
Control group	Popmeter®	The control group will be allocated to rest in a dedicated room without napping between 1 am and 4 am.
Nap group	Epworth questionnaire	The experimental group will be allocated to do a 30-min on-duty nap during night work, in a dedicated room between 1 am and 4 am.
Nap group	The Karolinska Sleepiness Scale	The experimental group will be allocated to do a 30-min on-duty nap during night work, in a dedicated room between 1 am and 4 am.
Control group	Control condition (30-min rest)	The control group will be allocated to rest in a dedicated room without napping between 1 am and 4 am.
Control group	EndoPAT	The control group will be allocated to rest in a dedicated room without napping between 1 am and 4 am.
Control group	Panasonic EW3109	The control group will be allocated to rest in a dedicated room without napping between 1 am and 4 am.
Control group	Fasting blood sample	The control group will be allocated to rest in a dedicated room without napping between 1 am and 4 am.
Control group	Pichot fatigue scale	The control group will be allocated to rest in a dedicated room without napping between 1 am and 4 am.
Control group	The Short-Form 36 (SF-36)	The control group will be allocated to rest in a dedicated room without napping between 1 am and 4 am.
Control group	French version of the Recovery Needs Scale (BRD)	The control group will be allocated to rest in a dedicated room without napping between 1 am and 4 am.
Nap group	Popmeter®	The experimental group will be allocated to do a 30-min on-duty nap during night work, in a dedicated room between 1 am and 4 am.
Nap group	Pittsburgh Sleep Quality Index (PSQI)	The experimental group will be allocated to do a 30-min on-duty nap during night work, in a dedicated room between 1 am and 4 am.
Nap group	On-duty Nap	The experimental group will be allocated to do a 30-min on-duty nap during night work, in a dedicated room between 1 am and 4 am.
Nap group	Pichot fatigue scale	The experimental group will be allocated to do a 30-min on-duty nap during night work, in a dedicated room between 1 am and 4 am.
Control group	Pittsburgh Sleep Quality Index (PSQI)	The control group will be allocated to rest in a dedicated room without napping between 1 am and 4 am.
Control group	ECG Holter	The control group will be allocated to rest in a dedicated room without napping between 1 am and 4 am.
Nap group	ECG Holter	The experimental group will be allocated to do a 30-min on-duty nap during night work, in a dedicated room between 1 am and 4 am.
Nap group	The Short-Form 36 (SF-36)	The experimental group will be allocated to do a 30-min on-duty nap during night work, in a dedicated room between 1 am and 4 am.
Nap group	Actimeter	The experimental group will be allocated to do a 30-min on-duty nap during night work, in a dedicated room between 1 am and 4 am.
Control group	Epworth questionnaire	The control group will be allocated to rest in a dedicated room without napping between 1 am and 4 am.
Control group	The Karolinska Sleepiness Scale	The control group will be allocated to rest in a dedicated room without napping between 1 am and 4 am.
Control group	Actimeter	The control group will be allocated to rest in a dedicated room without napping between 1 am and 4 am.

Primary Outcome Measures

Name	Time	Method
Evolution of reactive hyperemia index (RHI)	Change between week 1 and 12	RHI is measured through the EndoPAT device® initially and at 12 weeks, and corresponds to the vascular reactivity following a 5-min occlusion on an arm

Secondary Outcome Measures

Name	Time	Method
Evolution of pro-inflammatory biomarkers	Change between week 1 and 12	Fasting blood sample to measure hsCRP, IL-6 TNF-α, IL-1β initially and at 12 weeks.
Evolution of alertness at work assessed	Change between week 1 and 12	The Karolinska Sleepiness Scale measures daytime sleepiness on a 9-point scale, based on 5 states and 4 intermediate states that are not verbally indicated, initially and at 12 weeks.
Evolution of sleep time	Change between week 1 and 12	Actimeter measuring variations in wake-up and bedtimes, sleep duration, energy expenditure and time spent at different levels of physical activity intensity (sedentary, light intensity, moderate to intense intensity), initially and at 12 weeks.
Evolution of sleep duration	Change between week 1 and 12	Actimeter measuring variations in wake-up and bedtimes, sleep duration, energy expenditure and time spent at different levels of physical activity intensity (sedentary, light intensity, moderate to intense intensity), initially and at 12 weeks.
Evolution of pulse wave velocity (PWV)	Change between week 1 and 12	PWV is measured through the Popmeter® initially and at 12 weeks, and corresponds to the finger-o-foot pulse wave velocity(m/s)
Evolution of blood markers of endothelial function	Change between week 1 and 12	Fasting blood sample to measure NO, SOD, IL-18 initially and at 12 weeks.
Evolution of subjective Fatigue	Change between week 1 and 12	The Pichot fatigue scale (composed of 8 items, a score above 22 indicates excessive fatigue), initially and at 12 weeks.
Evolution of recovery Needs	Change between week 1 and 12	French version of the Recovery Needs Scale (BRD), initially and at 12 weeks, wich consists of 11 items coded 0 or 1. A score is calculated for each participant, multiplied by 10 to give a score ranging from 0 to 100. The greater the need for recovery, the higher the score.
Evolution of subjective sleepiness	Change between week 1 and 12	Epworth questionnaire, initially and at 12 weeks : 8-question sleepiness assessment scale, a score above 10 indicates excessive sleepiness
Evolution of blood pressure	Change between week 1 and 12	Systolic and diastolic blood pressure (mm Hg) measured in the sitting position in triplicate with an automatic blood pressure device (Panasonic EW3109) on the left arm, initially and at 12 weeks.
Evolution of heart rate variability (HRV)	Change between week 1 and 12	24-h Holter-Electrocardiogram to derive temporal (SDNN, rMSSD, pNN50) and frequency (LF, HF, LF/HF) HRV indices initially and at 12 weeks.
Evolution of state of health	Change between week 1 and 12	The SF-36 questionnaire is used to assess quality of life, initially and at 12 weeks. It comprises 8 sub-scores ranging from 0 (minimum quality of life) to 100 (maximum well-being).
Evolution of sleep quality	Change between week 1 and 12	Pittsburgh Sleep Quality Index (PSQI), initially and at 12 weeks : 24-question sleep quality assessment scale, a score \> 5 indicates poor sleep quality.

Trial Locations

Locations (1)

Chu de Saint-Etienne; 🇫🇷 Saint-Étienne, France