A cross-sectional study to assess night-shift work related exposures and their association with markers of biological perturbatio
- Conditions
- Biomarkers, circadian and biological disruption markersstress markers (cortisol) and 24-hour rhythm markers (melatonin)
- Registration Number
- NL-OMON43599
- Lead Sponsor
- niversiteit Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 300
- Subject is between 18 years and 65 years of age by the time of performing the screening questionnaire.
- Subjects are female.
- Subjects are nurse or employed in a paramedic profession.
- Subjects either have not worked in a profession requiring shift work for over 5 years, just started working in night shifts (<2 year) or worked in night-shifts for over 5 years.
- Subjects are willing to give blood, fill out the questionnaires, and wear the sensors.;For the sub-study the same inclusion criteria apply with the exception of the last one. This criterion is replaced with:
- Subjects are willing to give blood and fill out the questionnaires.
- Subject is a smoker or ex-smoker for less than 6 months since baseline of study inclusion. Occasional smokers that have smoked less than 100 cigarettes in their lifetime are considered non-smokers.
- Subject has a doctor diagnosed chronic disease/disorder (i.e. CVD, metabolic syndrome, diabetes).
- Subject has/had cancer excluding non-melanoma skin cancer.
- Subject uses beta-blockers, or melatonin supplementation.
- Subject was pregnant in the last 6 months or is planning to become pregnant in the next 12 months.
- Subject is in fertility treatment.;Exclusion criteria for the sub-study are the same
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method