Comparative Efficacy of Carbetocin and Oxytocin in Parturients at Risk of Atonic Postpartum Hemorrhage Undergoing Elective Cesarean Delivery
- Conditions
- Post Partum Hemorrhage
- Registration Number
- NCT06333340
- Lead Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Female
- Target Recruitment
- Not specified
Inclusion criteria - Any one or more of the risk factors for uterine atony:<br><br> - Overdistended uterus due to:<br><br> - Polyhydramnios (amniotic fluid index >24 cm)<br><br> - Fetal macrosomia reported on prenatal ultrasound >90th centile or > 4000 gm<br><br> - Multiple gestation<br><br> - History of uterine atony/PPH (documented with blood loss of >1000 ml, blood<br> transfusion, use surgical methods such as Bakri balloon, B-Lynch sutures, uterine<br> artery ligation or embolization)<br><br> - Obesity with body mass index (BMI) >40 kg/m2<br><br> - Diabetes mellitus on treatment<br><br> - Preeclampsia on treatment<br><br> - Placenta previa<br><br>Exclusion criteria:<br><br> - Valvular heart disease, arrhythmias, or heart failure<br><br> - Placenta accreta spectrum<br><br> - Bleeding disorder<br><br> - Anemia (<100 g/dl)<br><br> - Allergy or sensitivity to oxytocin or carbetocin
Not provided
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Proportion of parturients requiring additional uterotonic agents intraoperatively
- Secondary Outcome Measures
Name Time Method