A comparison of Oxytocin andCarbetocin for the prevention of postpartum haemorrhage in high risk patients undergoing cesarean delivery

Not Applicable

• Registration Number: CTRI/2023/03/050426
• Lead Sponsor: PDU Govt Medical College Rajkot

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 3 April 2023

Recruitment & Eligibility

• Status: ot Yet Recruiting
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

High risk pregnant patients posted for elective cesarean delivery under spinal anaesthesia of ASA Grade III and IV with 35-40 weeks of gestation, Multiple pregnancies, Previous cesarean scar, Presence of uterine fibroids, Previous myomectomy, Presence of placenta previa, Past history of PPH

Exclusion Criteria

Hypertension, Preeclampsia, Cardiac diseases, Renal diseases, Liver diseases, Epilepsy, Neuromuscular diseases, Severe anemia, General Anaesthesia, Women with history of hypersensitivity to carbetocin/oxytocin, Patient refusal

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To assess the efficacy of Oxytocin and Carbetocin in terms of intraoperative blood loss, additional uterotonic needed and adverse effects if any in caesarean delivery with high risk of post-partum haemorrhage. To compare the hemodynamic effects of Oxytocin and Carbetocin (effects on heart rate and blood pressure) <br/ ><br>Timepoint: Heart rate and blood pressure noted before skin incision, after 1 minute, 3 minutes, 5 minutes, at the time of skin closure, after 2 hours, after 12 hours. Uterine tone noted at time of delivery and after 3 minutes, 6 minutes, 9 minutes, 12 minutes, 2 hours, 12 hours. <br/ ><br>

Secondary Outcome Measures

Name	Time	Method
1)Demographic data <br/ ><br>2)Uterine tone <br/ ><br>3)Additional uterotonic used <br/ ><br>4)Additional side effectsTimepoint: 1)Maternal Age(years) and Gestational Age(weeks) <br/ ><br>2)Likert Scale at time of delivery, after 3 minutes, after 6 minutes, after 9 minutes, after 12 minutes after 2 hours, after 12 hours(Likert scale 0-4, 0-floppy,1-soft, 2-poorly contracted, 3-well contracted, 4-hard rock) <br/ ><br>3)Additional uterotonics used <br/ ><br>4)Nausea, Vomitting, Flushing, Tachycardia, Hypotension, Headache, Chestpain <br/ ><br>