Investigating the effect of atorvastatin and aspirin on liver cirrhosis

Phase 4

Conditions: Toxic liver disease with fibrosis and cirrhosis of liver.
Toxic liver disease with fibrosis and cirrhosis of liver
K71.7

Registration Number: IRCT20231002059591N1

Lead Sponsor: Zahedan University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: 81

Inclusion Criteria

Patients with liver cirrhosis who were diagnosed with symptoms
Age 18-75
Ultrasound based on cirrhosis

Exclusion Criteria

pregnant woman
Statin use in the last year
affected hcc
LDL >70
Myopathy caused by atherostatin treatment
meld>23
child pugh>13
Evidence of infection in the last 4 weeks
Hepatornal syndrome in clinical and biochemical evidence in the last 14 days
High hepatic encephalopathy 2
3 times increase of aminotransferase in 3 months after starting the study
Recent use of febrate, varithromycin and others
useP450 inhibitor
Esophageal varices
Patient dissatisfaction

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
CK: One of the body's muscle enzymes. Timepoint: Every three months to a year. Method of measurement: Measurements from the patient's blood sample.;AST :SGOT is an enzyme from the group of transferases. In fact, it is a PLP-dependent transaminase that is mainly found in the liver. Timepoint: Every three months to a year. Method of measurement: Measurements from the patient's blood sample.;It is an enzyme found mainly in the liver, but small amounts are also found in the kidneys, heart, muscles, and pancreas. (SGPT). Timepoint: Every three months to a year. Method of measurement: Measurements from the patient's blood sample.;PT:Blood clotting time. Timepoint: Every three months to a year. Method of measurement: Measurements from the patient's blood sample.;PLT:The number of platelets in the serum. Timepoint: Every three months to a year. Method of measurement: Measurements from the patient's blood sample.

Secondary Outcome Measures

Name	Time	Method
Fib_4 index:Fibrosis index base on index-Non-invasive indicator of liver fibrosis. Timepoint: Every three months to a year. Method of measurement: It is calculated based on age and platelets and AST in the formula.;Non-invasive indicator of liver fibrosis-Ast to platlet retio index. Timepoint: Every three months to a year. Method of measurement: It is calculated based on AST and PLT in the formula.