functional MRI study to evaluate improvement of hand performance after combined motor exercise and aminopiridine assumptio
- Conditions
- Patients with MS, without relevant medical conditions, with right upper limb impairment assessed by a hand dexterity test will be included.Patients will be in a non-active phase of the disease and under a stable pharmacological treatment.They will not be included if they have received physiotherapy in the previous few months. Healthy volunteers will be recruited if they have no relevant medical condition and no contraindication to perform a MRI scan.MedDRA version: 14.1Level: LLTClassification code 10028053Term: MSSystem Organ Class: 10029205 - Nervous system disordersTherapeutic area: Diseases [C] - Nervous System Diseases [C10]
- Registration Number
- EUCTR2012-000287-17-IT
- Lead Sponsor
- FONDAZIONE SANTA LUCIA
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Authorised-recruitment may be ongoing or finished
- Sex
- All
- Target Recruitment
- Not specified
Right handed Multiple Sclerosis patients without relapses in the previous year and, if under pharmacological treatment, with a stable dose regimen for at least 3 months. Patients will be included if they present with a right hand dexterity impairment (average of 2 performances in 9-hole peg test: >30 seconds).
Are the trial subjects under 18? no
Number of subjects for this age range: 0
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range 100
F.1.3 Elderly (>=65 years) no
F.1.3.1 Number of subjects for this age range
Rehab in the previous 6 months; significant cognitive deficit that may prevent engagement in the study; contraindications to MRI scan; allergy to the drug or the eccipients; any relevant pathology that contraindicate drug intake.
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method