Frailty Index as An Indicator Associated With Postoperative Adverse Outcomes In The Older Population
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 12,000
- 试验地点
- 1
- 主要终点
- 1-month all-cause mortality
研究概览
简要总结
This study is a observational study in China, which aims to explore the predictive effect of preoperative frailty defined by the modified frailty index in predicting postoperative survival and complications in elderly patients.
The objectives of the study include:
- To demonstrate that the frailty scale can predict short- and long-term survival after surgery in elderly surgical patients; 2 Demonstrated that frailty as defined by this scale is associated with postoperative complications in older patients
详细描述
Traditionally, frailty has been described as the form of chronological age. Evaluating the patient's risks based solely on age is difficult, several other factors contribute to physiologic aging and determine functional reserve and response to the risk of postoperative complications. To meet the clinical demand for simpler frailty measurement tools, a simplified 5-index modified frailty index (mFI-5) has been proposed and validated in many literatures. However, there is a lack of evidence on the link between preoperative weakness and poor prognosis in elderly patients undergoing non cardiac surgery.
Therefore, the purpose of this study is to verify the prognostic value of mFI-5 for short-term and long-term adverse outcomes such as postoperative delirium, anxiety, depression, acute pain, and mortality in elderly non-cardiac surgery patients. Our hypothesis is that frailty may be highly correlated with postoperative mortality and adverse outcomes in elderly patients undergoing non-cardiac surgery, and that mFI-5 may be an effective risk prediction tool for decision-making and surgical planning.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •(1) participants ≥ 65 years of age;
排除标准
- •lacked any covariate indicator or missing data for any confounder (such as demographic information, intraoperative surgery or anesthesia information);
- •ASA physical status Ⅴ;
- •Anesthesia other than general intravenous anesthesia or intravenous inhalation anesthesia;
- •Surgery time ≤ 60 min.
结局指标
主要结局
1-month all-cause mortality
时间窗: postoperative 1-month
1-month postoperative mortality in elderly patients over 65 years of age
12-month all-cause mortality
时间窗: postoperative 12-month
12-month postoperative mortality in elderly patients over 65 years of age
6-month all-cause mortality
时间窗: postoperative 6-month
6-month postoperative mortality in elderly patients over 65 years of age
次要结局
- Readmission rates(postoperative 30-day)
- Admission to ICU(From the moment of living operation room to the moment of discharge from hospital,up to 7 day)
- major complications(From the moment of living operation room to the moment of discharge from hospital,up to 7 day)
研究者
Weidong Mi
Director of anesthesiology department
Chinese PLA General Hospital