ew therapeutic targets in stroke prevention: the effect of allopurinol on the cerebral vasculature of patients with subcortical stroke

Phase 1

• Conditions: Subcortical Ischaemic Stroke

• Registration Number: EUCTR2005-001669-33-GB
• Lead Sponsor: Greater Glasgow NHS Health Board / University of Glasgow co-sponsorship

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2005-10-13
• Last Update Posted: 27 July 2020

Recruitment & Eligibility

• Status: ot Recruiting
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

1. Subcortical ischaemic stroke
2. Index stroke between two weeks and three months prior to randomisation

Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range

Exclusion Criteria

1. >70% extra-cranial internal carotid artery stenosis
2. Known coronary arterial disease
3. Significant co-morbidity
4. Contra-indication to or indication for administration of allopurinol
5. Contra-indication to administration of acetazolamide
6. Concurrent azathioprine or 6-mercaptopurine therapy
7. Serum creatinine concentration greater than 250 micromoles per litre

Study & Design

• Study Type: Interventional clinical trial of medicinal product
• Study Design: Not specified