ew therapeutic targets in stroke prevention: the effects of allopurinol on the cerebrovasculature of patients with subcortical stroke
Completed
- Conditions
- Subcortical stroke.Circulatory SystemStroke
- Registration Number
- ISRCTN06452574
- Lead Sponsor
- Greater Glasgow NHS Board/Glasgow University (UK)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria
1. Subcortical stroke
2. Index stroke within 2 weeks and 3 months prior to randomisation
Exclusion Criteria
1. >70% Internal carotid artery stenosis
2. Coronary artery disease
3. Other significant comorbidity
4. Contraindication to allopurinol
5. Contraindication to acetazolamide
6. Concurrent azathioprine or 6-mercaptopurine therapy
7. Serum creatinine >250 µmol/l
8. Woman of childbearing potential
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The change in flow velocity in the middle cerebral artery (MCA) following acetazolomide infusion.
- Secondary Outcome Measures
Name Time Method 1. Change in serum urate<br>2. Recurrent stroke or other cardiac event