Screening for COVID-19 in Teachers, Childcare Educators, Pupils and Preschoolers
- Conditions
- SARS-CoV-2
- Interventions
- Diagnostic Test: Nasopharyngeal swabDiagnostic Test: Serum testing
- Registration Number
- NCT04619407
- Lead Sponsor
- University Medicine Greifswald
- Brief Summary
The main objectives of this study are
1. to establish the prevalence of SARS-CoV-2 in schools and kindergartens in the State of Mecklenburg-Vorpommern in autumn and winter 2020/2021
2. to monitor the future spread of the disease by assessing serological responses to SARS-CoV-2 in teachers and childcare educators over time
- Detailed Description
Detailed Description:
This study aims to collect information on teachers and childcare educators as well as on pupils and preschoolers in the State of Mecklenburg-Vorpommern
Over a 5 month period, 5 study visits per participant are planned. At each visit, nasal/throat swabs (for PCR testing) will be collected and participants will be asked to fill in a questionnaire (asking for SARS-CoV-2 risk factors, perceived risk, and impact of the pandemic on their quality of life). In adults, additional blood samples (for SARS-CoV-2 antibody testing) will be collected at the first and the last study visit. This will help to gain a better understanding of viral load and antibody development over time.
The remaining blood samples will be stored in a repository for future research.
The study is part of a modular SARS-CoV-2-research programme of the University Medicine Greifswald.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 142
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description teacher Serum testing * Employed in a school in Mecklenburg-Vorpommern * Age between 18 to 67 years * Willing and able to provide informed consent * Over 5 months: Monthly nasopharyngeal swabs for SARS-CoV-2 PCR, additionally blood samples for SARS-CoV-2 antibody testing will be taken at the beginning and at the end of the study childcare educators Nasopharyngeal swab * Employed in a kindergarten in Mecklenburg-Vorpommern * Age between 18 to 67 years * Willing and able to provide informed consent * Over 5 months: Monthly nasopharyngeal swabs for SARS-CoV-2 PCR, additionally blood samples for SARS-CoV-2 antibody testing will be taken at the beginning and at the end of the study pupils Nasopharyngeal swab * Attending school in Mecklenburg-Vorpommern * Age between 6 to 17 years * Agreement to participate * Legal representative willing and able to provide informed consent * Over 5 months: Monthly nasopharyngeal swabs for SARS-CoV-2 PCR childcare educators Serum testing * Employed in a kindergarten in Mecklenburg-Vorpommern * Age between 18 to 67 years * Willing and able to provide informed consent * Over 5 months: Monthly nasopharyngeal swabs for SARS-CoV-2 PCR, additionally blood samples for SARS-CoV-2 antibody testing will be taken at the beginning and at the end of the study preschoolers Nasopharyngeal swab * Attending kindergarten in Mecklenburg-Vorpommern * Age between 3 to 6 years * Agreement to participate * Legal representative willing and able to provide informed consent * Over 5 months: Monthly nasopharyngeal swabs for SARS-CoV-2 PCR teacher Nasopharyngeal swab * Employed in a school in Mecklenburg-Vorpommern * Age between 18 to 67 years * Willing and able to provide informed consent * Over 5 months: Monthly nasopharyngeal swabs for SARS-CoV-2 PCR, additionally blood samples for SARS-CoV-2 antibody testing will be taken at the beginning and at the end of the study
- Primary Outcome Measures
Name Time Method Share of participants with SARS-CoV-2 detectable in PCR 5 months Percentage of SARS-CoV-2 PCR positive participants (children and educational staff)
- Secondary Outcome Measures
Name Time Method SARS-CoV-2 risk factors, perceived risk of infection, and impact of the pandemic on quality of life 5 months As assessed by a monthly questionnaire
Seroprevalence of SARS-CoV-2 antibodies 5 months Percentage of Anti-SARS-COV2 S protein IgA and IgA ELISA positive participants (educational staff)
Share of participants with SARS-CoV-2 detectable in PCR 4 months Percentage of SARS-CoV-2 PCR positive participants (children and educational staff)
Trial Locations
- Locations (1)
Greifswald University Medicine
🇩🇪Greifswald, Germany