Capsaicin induced neurogenic inflammation of the skin: influence of migraine and estrogen level
- Conditions
- headache10019231
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 66
General
• Women
• Age between 18 and 75 years
• Non-smoking for > 6 months
• Body mass index between 18 and 30
• Capable and willing to give informed consent
• General good health, based on medical history and physical examination;Subjects with migraine:
• Should have diagnosed migraine, fulfilling criteria 1.1. Migraine without aura of International Classification of Headache Disorders (ICHD).
• Migraine attacks should occur exclusively on day 1±2 (ie, days -2 to +3) of menstruation in at least two out of three menstrual cycles and additionally at other times of the cycle.
• Should have a natural and regular menstrual cycle
• Age between 18 and 45 years;Subjects without migraine:
• Should have a natural and regular menstrual cycle
• Age between 18 and 45 years
Postmenopausal subjects
• Should be amenorrhoeic for at least 1 year
• Use of hormonal contraceptives or hormonal replacement therapy
• History of cardiovascular disease
• Any serious illness that can compromise study participation
• Regular use of medication outside the period of migraine attacks
• Dermal diseases at the upper frontal side of the face
• Pregnancy or breastfeeding
• History of sensitivity to the fruits of capsicum plants (eg chilli peppers)
• Alcohol or drug abuse
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Differences in capsaicin-induced vasodilatation between women with and without<br /><br>migraine.<br /><br>Effect of estrogen en progesterone levels on the capsaicin induced<br /><br>vasodilatation. </p><br>
- Secondary Outcome Measures
Name Time Method <p>not applicable</p><br>