The Effect of Pasteurized; Pasteurized and Homogenized and UHT Treated Homogenized Cow's Milk on Gastrointestinal Symptoms in Sensitive Adults

Not Applicable

Completed

• Conditions: Unidentified Gastrointestinal Discomfort Following Dairy Consumption
• Interventions: Other: Dietary intervention

• Registration Number: NCT03010904
• Lead Sponsor: University of Turku

Brief Summary

This study aims to investigate differences in digestion rates and gastrointestinal problems caused by pasteurized; pasturized and homogenized as well as UHT-treated homogenized cow's milks in healthy adults by diary of symptoms, blood glucose and triacylglycerol levels and plasma cytokine levels.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-01
• Study First Submitted: 2017-01-04
• Study First Submitted QC: 2017-01-04
• Study First Posted: 2017-01-05
• Primary Completion: 2018-05
• Study Completion: 2018-05
• Status Verified: 2022-05
• Last Update Submitted: 2022-05-24
• Last Update Posted: 2022-05-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 14

Inclusion Criteria

• Homogenized and pasteurized milk causes gastrointestinal problems (self-reported) unhomogenized and unpasteurized milk does not cause gastrointestinal problems (self-reported)
• age 18-65
• BMI 18,5 - 30
• hemoglobin under normal range
• fasting plasma alanine aminotransferase ALAT < 60 U/l (normal liver function)
• fasting plasma thyroid-stimulating hormone (TSH) 0.4 - 4.5 mU/l (normal thyroid function)
• fasting plasma creatinine < 118 umol/l (normal kidney function)

Exclusion Criteria

• pace maker
• Crohn's disease or other disease of the intestinal tract
• intestinal operation within the last 3 months
• difficult dysphagia
• smoking
• constipation
• lactose intolerance
• coeliac disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
pasteurized milk	Dietary intervention	milk that has undergone pasteurization treatment
homogenized pasteurized milk	Dietary intervention	Milk that has undergone homogenization and pasteurization treatment
UHT milk	Dietary intervention	Milk that has undergone homogenization and ultra high temperature treatment

Primary Outcome Measures

Name	Time	Method
Gastrointestinal symptoms (self reported)	day 0 - day 5	Gastrointestinal symptoms (self-reported) as measured by a questionnaire. The questionnaire is devided into seven types of gastrointestinal discomfort, and also includes a possibility to describe a gastrointestinal discomfort outside these seven given alternatives. The severity of the symptoms is self-reported on a three-step scale.

Secondary Outcome Measures

Name	Time	Method
Plasma glucose	20 min, 40 min, 60 min, 120 min, 180 min, 240 min, 300 min
Plasma triacylglycerols	20 min, 40 min, 60 min, 120 min, 180 min, 240 min, 300 min
Plasma insulin	20 min, 40 min, 60 min, 120 min, 180 min, 240 min, 300 min

Trial Locations

Locations (2)

Department of Biochemistry, University of Turku; 🇫🇮 Turku, Finland

Food Chemistry, Department of Biochemistry, University of Turku; 🇫🇮 Turku, Finland