Study on the Safety and Effectiveness of Guanxinning Tablets in Intensive Therapy for Patients with Acute Coronary Syndrome
- Conditions
- Acute Coronary Syndrome
- Registration Number
- ITMCTR2100005434
- Lead Sponsor
- Hangzhou First People's Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- Not specified
Diagnostic criteria for acute myocardial infarction: elevated cardiac troponin (cTn), at least once the value is higher than the upper limit of 99% of the reference value, and at least one of the following: ? symptoms of acute myocardial ischemia; ? new ischemia ECG changes; ? pathological Q waves; (4) imaging evidence of newly viable myocardium loss or new segmental ventricular wall motion abnormalities. If ECG manifests as ST-segment elevation in two or more adjacent leads, new left bundle branch block or hyperacute T wave changes, it is defined as SETMI. If there is no ST-segment elevation on the ECG at the time of consultation, it is defined as NSTEMI. Diagnostic criteria for unstable angina (UA): ?Including first-onset exertional angina, worsening exertional angina, resting angina, and variant angina; ?ischemic chest pain time =30min; ?The ECG showed ST-segment level or Decline depression = 1 mm or ST segment elevation (limb leads = 1 mm, chest leads = 2 mm), after the onset, the ST segment returns to the level before the onset; ? no changes in blood myocardial necrosis markers.
?Age <18 years; ?Recent fever, various acute and chronic infections, past strokes, malignant tumors, rheumatic connective tissue disease, etc.; ?Severe heart, liver, and kidney insufficiency; ?Recent activities (2-4 weeks) Visceral hemorrhage, including head trauma, cardiopulmonary resuscitation, major surgery, puncture on large blood vessels that cannot be compressed, or known bleeding tendency; ?Severe and uncontrolled hypertension at admission (>180/110mmHg) ); ? pregnant women, breast-feeding women; ? allergic constitution, or food allergies to multiple drugs; (8) patients who have participated in clinical trials of other drugs within 1 month.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Antiplatelet aggregation rate;Inflammation-related factors (TNF-a, IL-1, IL-6, IL-10);Hypersensitive-c-reactive-protein;Oxidative stress indicators (SOD, ROS);Troponin T;Nitric Oxide;Electrocardiogram;Creatine Kinase, MB Form;
- Secondary Outcome Measures
Name Time Method