Serum Dickkopf-1 and Its Association with Bone Mineral Density in Children and Adolescents with Congenital Adrenal Hyperplasia
Not Applicable
- Conditions
- Serum Dickkopfǃ concentration in children and adolescents with 21-hydroxylase deficiency Bone mineral density in children and adolescents with 21-hydroxylase deficiency Association between serum
- Registration Number
- TCTR20201109004
- Lead Sponsor
- Research affairs, Faculty of Medicine, Khon Kaen University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending (Not yet recruiting)
- Sex
- All
- Target Recruitment
- 35
Inclusion Criteria
1. Children and adolescents ages 8-20 years
2. Diagnosed with classic 21-hydroxylase deficiency: 17-hydroxyprogesterone >10,000 ng/dl and peak cortisol <18 ug/dl after 250-ug ACTH test
3. Treated and follow up at Khon Kaen University Hospital
Exclusion Criteria
Participants with the following conditions will be excluded:
1. Diseases or medications affecting bone and vitamin D metabolism except glucocorticoid, calcium and vitamin D
2. Pathological fracture
3. Current or recent (< 6 months) fractures or wearing prostheses or instruments around the BMD measurement site
4. Deformity of the bone at the BMD measurement site
5. Pregnancy
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Serum Dickkopf-1 This is a cross-sectional study (only 1 time point - on study visit) ELISA
- Secondary Outcome Measures
Name Time Method umbar bone mineral density This is a cross-sectional study (only 1 time point - on study visit) DXA scan