Assessing levels of Periostin and DKK-1, for periodontal disease and diabetes before and after treatment.
Not Applicable
- Conditions
- Health Condition 1: E119- Type 2 diabetes mellitus without complications
- Registration Number
- CTRI/2023/04/051408
- Lead Sponsor
- Suganya T
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
subjects with diagnosis of stage III grade B periodontitis.
well controlled diabetes subjects will be selected.
subjects should not have atleast 20 natural teeth excluding third molars.
subjects with normal lipid profile.
Exclusion Criteria
pregnant and lactating females. smokers and alcoholics
subjects with other systemic conditions rheumatoid arthritis, cardiovascular abnormalities, use of immunosuppressive medications, and other infectious chronic diseases.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare and correlate the clinical parameters and levels of Periostin and DKK1 in <br/ ><br>GCF and Serum in periodontally healthy, stage III Grade B periodontitis subjects with and without Type 2 Diabetes mellitus before and 3 months after NSPTTimepoint: 12 weeks
- Secondary Outcome Measures
Name Time Method 1. To estimate the levels of Periostin and DKK-1 in the gingival crevicular (GCF) and serum in systemically and periodontally healthy subjects, Stage III Grade B periodontitis patients with and without Type 2 diabetes mellitus. <br/ ><br>2.To estimate the levels of Periostin and DKK-1 in the GCF and serum in Stage III Grade B periodontitis patients with and without Type 2 diabetes mellitus patients 3 months after NSPT. <br/ ><br>3. To explore the possibility of using DKK-1 as a bone resorptive marker in periodontal disease progression.Timepoint: 12 weeks