Co relation of perfusion index with non invasive haemodynamic parameters to evaluate stress response in neurosurgical cases under general anaesthesia
试验速览
- 阶段
- Unknown
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 55
- 试验地点
- 1
- 主要终点
- The primary outcome is to establish whether changes in perfusion index can be used as a new method to evaluate stress response in neurosurgical cases.Perfusion index will be correlated with heart rate at specific time points.
研究概览
简要总结
Perfusion index is a non invasive and indirect measure of peripheral perfusion obtained from pulse oximeter. It is calculated by expressing the pulsatile signal as a percentage of the non pulsatile signal, both of which are derived from the amount of infrared(940) light absorbed, It is measured at specific site such as fingers and toes. It can be used to assess peripheral perfusion dynamics due to changes in the sympathetic tone.
The concept of neuroanaesthesia includes several principles, haemodynamic stability perioperatively being one of utmost importance. Anaesthetic maneuvers like direct laryngoscopy, tracheal intubation and extubation involve sympathetic stimulation. Surgical interventions in the form of skull pins, incision and craniotomy are also critical points of intense stimulation. All these cause marked alterations in mean arterial flow, cerebral blood flow and intracranial pressure which may result in raised Intracranial pressure with reduction in cerebral perfusion pressure. Perioperative hypertension is associated with intracranial bleeds
Thus, the prevention of haemodynamic responses to nociceptive stimuli to preserve cerebal haemostasis is of utmost importance.
The aim of this study is to establish whether changes in perfusion index can be used a a new method to evaluate stress response during neurosurgery and to compare its reliability with conventional non invasive haemodynamic parameters( heart rate, systolic blood pressure) during period of stress under general anaesthesia.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •1.Age 18-65 years 2.ASA I AND II.
排除标准
- •pregnant female
- •h/o chronic hypertension
- •h/o diabtes mellitus
- •h/o peripheral vascular disease.
结局指标
主要结局
The primary outcome is to establish whether changes in perfusion index can be used as a new method to evaluate stress response in neurosurgical cases.Perfusion index will be correlated with heart rate at specific time points.
时间窗: 1) At the time of intubation-readings noted every minute for five minutes | 2)At the time of insertion of skull pins- readings noted every minute for five minutes | 3) At the time of skin incision- readings noted every minute for five minutes | 4) At the time of craniotomy-readings noted every minute for five minutes
次要结局
- To compare sensitivity and specificity of perfusion index with conventional non invasive haemodynamic parameters(ie heart rate, systolic blood pressure) during periods of stress in neurosurgical cases under general anaesthesia.(1)At time of intubation)