To see the relation between finger tip blood flow with pulse and blood pressure in patients operated for brain surgery under general anaesthesia.

Not Applicable

Active, not recruiting

Conditions: Studying the parameters viz. heart rate, blood pressure and perfusion index to evaluate stresss response in patients undergoing neurosurgical procedures

Registration Number: CTRI/2016/06/007050

Lead Sponsor: Lokmanya Tilak Municipal General Hospital

Brief Summary: Perfusion index is a non invasive and indirect measure of peripheral perfusion obtained from pulse oximeter. It is calculated by expressing the pulsatile signal as a percentage of the non pulsatile signal, both of which are derived from the amount of infrared(940) light absorbed, It is measured at specific site such as fingers and toes. It can be used to assess peripheral perfusion dynamics due to changes in the sympathetic tone.

The concept of neuroanaesthesia includes several principles, haemodynamic stability perioperatively being one of utmost importance. Anaesthetic maneuvers like direct laryngoscopy, tracheal intubation and extubation involve sympathetic stimulation. Surgical interventions in the form of skull pins, incision and craniotomy are also critical points of intense stimulation. All these cause marked alterations in mean arterial flow, cerebral blood flow and intracranial pressure which may result in raised Intracranial pressure with reduction in cerebral perfusion pressure. Perioperative hypertension is associated with intracranial bleeds

Thus, the prevention of haemodynamic responses to nociceptive stimuli to preserve cerebal haemostasis is of utmost importance.

The aim of this study is to establish whether changes in perfusion index can be used a a new method to evaluate stress response during neurosurgery and to compare its reliability with conventional non invasive haemodynamic parameters( heart rate, systolic blood pressure) during period of stress under general anaesthesia.

Detailed Description: Not available

Recruitment & Eligibility

Status: Closed to Recruitment of Participants

Sex: All

Target Recruitment: 55

Inclusion Criteria

1.Age 18-65 years 2.ASA I AND II.

Exclusion Criteria

pregnant female 2.
h/o chronic hypertension 3.
h/o diabtes mellitus 4.
h/o peripheral vascular disease.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary outcome is to establish whether changes in perfusion index can be used as a new method to evaluate stress response in neurosurgical cases.Perfusion index will be correlated with heart rate at specific time points.	1) At the time of intubation-readings noted every minute for five minutes \| 2)At the time of insertion of skull pins- readings noted every minute for five minutes \| 3) At the time of skin incision- readings noted every minute for five minutes \| 4) At the time of craniotomy-readings noted every minute for five minutes

Secondary Outcome Measures

Name	Time	Method
To compare sensitivity and specificity of perfusion index with conventional non invasive haemodynamic parameters(ie heart rate, systolic blood pressure) during periods of stress in neurosurgical cases under general anaesthesia.	1)At time of intubation

Trial Locations

Locations (1): Neurosurgical Operation Theatre
🇮🇳
Mumbai, MAHARASHTRA, India
Neurosurgical Operation Theatre
🇮🇳Mumbai, MAHARASHTRA, India
Dr Devangi Parikh
Principal investigator
9820471638
sdevangi10@gmail.com