Prospective observational trial of intraoperative use of vasopressor and inotropic drug infusion in elective cancer surgeries.

**Background:**Intraoperative hypotension is common in major oncological surgeries due to factors like hypovolemia, decreased systemic vascular resistance (SVR), and decreased inotropicity. Considering the complications associated with excessive fluid administration ,fluid management strategies have shifted towards conservative fluid therapy . This approach often necessitates the use of vasopressors and/or inotropes to maintain normal blood pressure. A rise in renal injury with restrictive fluid management is highlighted by many recent studies. Balanced fluid therapy, aiming for specific hemodynamic targets, has led to increased use of vasopressors. This study aims to understand the current patterns of intraoperative vasopressor and inotrope usage in elective cancer surgeries and determine the complications in these patients.

**Study Methodology:**All adult patients undergoing elective cancer surgery requiring intraoperative vasopressor or inotrope infusions will be enrolled in this prospective observational trial. Decision regarding vasopressor use will be made by attending anesthesiologists. Data will be collected prospectively from electronic and physical medical records. Revised Cardiac Risk Index will be calculated in all cases. Data collection will include demographic details, comorbidities, intraoperative variables, and postoperative outcomes. We will use the 5 point Major Adverse Cardiovascular Events (MACE ) criteria to determine postoperative cardiovascular complications.

Statistical Data Analysis

Descriptive Analysis descriptive statistics will be used to summarize the characteristics of the study population, including age, gender, comorbidities, type of cancer surgery, and the incidence of vasopressor/inotrope use. Continuous variables will be described using means and standard deviations, while categorical variables will be described using frequencies and percentages.