The effect of magnesium supplementation on hyperoxaluria and calcium oxalate supersaturation in kidney stone patients
- Conditions
- kidney stone.Calculus of kidneyN20.0
- Registration Number
- IRCT20191026045244N1
- Lead Sponsor
- Shahid Beheshti University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 99
Hyperoxaluria (24-hour urine oxalate over 40 and less than 80 mg)
Patients with a history of kidney stone referred to kidney stone prevention clinic of Labbafinejad
at least 20 days since the last treatment they have
at least 3 months since following general dietary advice on recurrence prevention (drinking advice, high oxalate food restriction, animal protein restriction, fruit and vegetable intake encouragement, salt restriction and fat intake modification)
willingness to cooperate in the study
Primary or enteric hyperoxaluria (urine oxalate>80 mg/24h)
Taking any drugs which affects calcium metabolism, including thiazides, potassium citrate, calcium supplement, magnesium supplement and Laxatives
Taking any drugs which affects oxalate metabolism or calcium oxalate supersaturation, including vitamin B6
History of diabetes mellitus, hepatic failure, thyroid or parathyroid diseases, chronic kiodney disease (CKD), Urinary tract infection (UTI), chronic diarrhea or immunologic diseases
Pregnancy or lactation
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 24 hour urine oxalate. Timepoint: Before the intervention, 8 weeks after intervention. Method of measurement: Enzymatic method.;Calcium oxalate supersaturation. Timepoint: Before the intervention, 8 weeks after intervention. Method of measurement: Calculation by LITHORISK software.
- Secondary Outcome Measures
Name Time Method 24 hour urine magnesium. Timepoint: Before the intervention, 8 weeks after intervention. Method of measurement: Chemical Method - Calorimetry.