Effect of probiotic in intestinal bacterial overgrowth in the irritable bowel syndrome patients
Phase 2
Completed
- Conditions
- Treatment of Irritable bowel syndrome.Irritable bowel syndrome
- Registration Number
- IRCT2013122815959N1
- Lead Sponsor
- Vice chancellor for research of Ahvaz Jondishapour University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 172
Inclusion Criteria
patients with irritable bowel syndrome based on ROME III criteria and small intestinal bacterial overgrowth based on positive hydrogen breath test. Exclusion criteria: patients with sensitivity to antibiotics, pregnancy, lactation, previous abdominal surgery, past medical history of hypothyroidism, celiac, malignancy, renal and liver insufficiency, diabetes and inflammatory bowel disease, familial history of colorectal carcinoma, ingestion of immunosuppressives and antibiotics in recent 2 months, ingestion of probiotics for more than 2 weeks in recent 6 months.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Expiratory hydrogene. Timepoint: After 10 days treatment with antibiotics and after 3 months treatment with probiotic. Method of measurement: Expiratory hydrogene with micro H2 and hydar hydrogene breath test after ingestion of 1 gram per kilogram body weight glucose in 150 ml water based on ppm.
- Secondary Outcome Measures
Name Time Method Incidence of adverse effects of probiotic. Timepoint: At the end of third month of treatment. Method of measurement: Asking from patients.