Ocular Changes With Alpha-2 Receptor Agonist.

Not Applicable

Recruiting

• Conditions: Glaucoma, Suspect; Aberration, Corneal Wavefront
• Interventions: Drug: Low dosage selective alpha-2 receptor agonists topical eyedrop; Drug: High dosage selective alpha-2 receptor agonists topical eyedrop

• Registration Number: NCT05670015
• Lead Sponsor: Benha University

Brief Summary

selective alpha-2 receptor agonists cause changes in intraocular pressure and pupillary size thus may affect patient quality of life.

Detailed Description

In this research, we will analyze the effect of selective alpha-2 receptor agonists on the human eye and investigate ocular changes over 6 months after its topical use.

Study Timeline

• Status Verified: 2023-01
• Study Start: 2023-01-01
• Study First Submitted: 2023-01-02
• Study First Submitted QC: 2023-01-02
• Last Update Submitted: 2023-01-02
• Study First Posted: 2023-01-04
• Last Update Posted: 2023-01-04
• Primary Completion: 2023-08-10
• Study Completion: 2023-09-22

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

• Glaucoma suspect cases.
• post-refractive surgery cases.

Exclusion Criteria

• Cases with prostatic hyperplasia or diabetics that may alter the measurements of pupillary diameter.
• Cases with previous history of any retinal intervention or other drugs that may alter intraocular pressure measurements.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Glaucoma suspect group	Low dosage selective alpha-2 receptor agonists topical eyedrop	Cases diagnosed as glaucoma suspect
Post-refractive surgery group	Low dosage selective alpha-2 receptor agonists topical eyedrop	Cases had undergone refractive surgery
Post-refractive surgery group	High dosage selective alpha-2 receptor agonists topical eyedrop	Cases had undergone refractive surgery
Glaucoma suspect group	High dosage selective alpha-2 receptor agonists topical eyedrop	Cases diagnosed as glaucoma suspect

Primary Outcome Measures

Name	Time	Method
Intraocular pressure	Baseline and 6 months after regular use of the topical eyedrops	Changes in intraocular pressure measured in mmHg by applanation tonometry

Secondary Outcome Measures

Name	Time	Method
Pupillary diameter	Baseline and 6 months after regular use of the topical eyedrops	Changes in the pupillary diameter measured in mm by handheld pupillometer

Trial Locations

Locations (1)

Ahmed Abdelshafy; 🇪🇬 Banhā, QA, Egypt