Effects of Systemic Drugs on Intraocular Pressure

• Conditions: Glaucoma Suspect; Glaucoma, Angle-Closure; Hypertension; Glaucoma Secondary to Drugs, Bilateral
• Interventions: Drug: Antihistaminics; Drug: Antihypertensive Agents

• Registration Number: NCT05328921
• Lead Sponsor: Benha University

Brief Summary

To assess intraocular pressure changes among glaucoma patients on systemic antihypertensive and antihistaminic drugs.

Detailed Description

Changes in intraocular pressure in glaucomatous patients with narrow angle may elicit attacks of angle closure glaucoma.

In this study we aim to assess changes in intraocular pressure (IOP) among glaucomatous patients on systemic antihypertensive and antihistaminic drugs.

Study Timeline

• Status Verified: 2022-04
• Study Start: 2022-04-07
• Study First Submitted: 2022-04-07
• Study First Submitted QC: 2022-04-07
• Last Update Submitted: 2022-04-07
• Study First Posted: 2022-04-14
• Last Update Posted: 2022-04-14
• Primary Completion: 2022-09-15
• Study Completion: 2022-09-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• patients with narrow angle glaucoma on systemic antihypertensive and/or antihistaminic drugs.

Exclusion Criteria

• open angle glaucoma patients confirmed by gonioscopy examination.
• Cases with dense corneal opacity or iris trauma that may affects gonioscopy examination.
• cases with secondary glaucoma.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Antihistaminic drugs group	Antihistaminics	Changes in IOP among patients on antihistaminic drugs
Antihypertensive drugs group	Antihypertensive Agents	Changes in IOP among patients on antihypertensive drugs
Antihypertensive and antihistaminic drugs group	Antihypertensive Agents	Changes in IOP among patients on both antihypertensive and antihistaminic drugs
Antihypertensive and antihistaminic drugs group	Antihistaminics	Changes in IOP among patients on both antihypertensive and antihistaminic drugs

Primary Outcome Measures

Name	Time	Method
Changes in intraocular pressure (IOP) measured by applanation tonometry	Immediately after visual acuity assessment for each eye after topical anesthetic eye drops and again on one and three months visit	Changes in IOP measured by millimeter mercury (mmHg)

Secondary Outcome Measures

Name	Time	Method
Changes in pupil diameter	Immediately after slit lamp examination and again on one and three months visit	Size of pupil measured in millimeters (mm) 7sing autorefractometer

Trial Locations

Locations (1)

Ahmed Abdelshafy; 🇪🇬 Banhā, QA, Egypt