Effect of Antihypertensive Drugs on Glaucoma Patients

• Conditions: Glaucoma
• Interventions: Other: no intervention

• Registration Number: NCT04943107
• Lead Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

Brief Summary

It has been reported that among Asian non-glaucomatous, antihypertensive medications were associated with retinal nerve fiber layer and ganglion cell-inner plexiform layer thickness. In order to explore whether antihypertensive medications would influence the neuropathy among glaucomatous population, we designed a cross-sectional observational study to analyze the retinal status among glaucoma patients with use of antihypertensive medication.

Detailed Description

we designed a cross-sectional obeservational study to analyze the retinal status among glaucoma patients with use of hyertensive medication.

Study Timeline

• Status Verified: 2021-05
• Study Start: 2021-05-01
• Study First Submitted: 2021-06-16
• Study First Submitted QC: 2021-06-27
• Last Update Submitted: 2021-06-27
• Study First Posted: 2021-06-29
• Last Update Posted: 2021-06-29
• Primary Completion: 2022-12-01
• Study Completion: 2022-12-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• age no less than 18 years

  • best corrected visual acuity better than decimal 0.3

Exclusion Criteria

• secondary glaucoma

  • secondary hypertension
  • glaucoma-related operation history
  • pregnancy or lactation period
  • uncooperative with retinal examination
  • severe opacity with refracting media in eye
  • severe retinal diseases and neuropathy
  • congenital retinal optic nerve abnormality
  • other systemic diseases that influence hypertension and glaucoma assessment

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
healthy control	no intervention	adults without glaucoma history or hypertension history
glaucoma+hypertension	no intervention	adults with primary glaucoma history and primary hypertension history; without glaucoma-related operation history
glaucoma patients	no intervention	adults with primary glaucoma history; without glaucoma-related operation history; without hypertension history
hypertension patients	no intervention	adults with primary hypertension history; without glaucoma history

Primary Outcome Measures

Name	Time	Method
retinal nerve fiber layer thickness	within 3 months from recruitment	retinal nerve fiber layer thickness measured by optical coherence tomography

Trial Locations

Locations (1)

2nd Affiliated Hospital, School of Medicine, Zhejiang University; 🇨🇳 Hangzhou, Zhejiang, China