Combined tDCS and Vision Restoration Training in Subacute Stroke Rehabilitation: A Pilot Study
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 14
- 试验地点
- 4
- 主要终点
- Change of mean sensitivity (in dB) detection threshold from baseline to post-intervention
研究概览
简要总结
The purpose of this Study is to determine whether non-invasive transcranial direct current stimulation (tDCS) is effective in increasing rehabilitation effects after stroke in visual Cortex.
详细描述
Visual field defects after posterior cerebral artery stroke can be improved by vision restoration training (VRT), but when combined with transcranial direct current stimulation (tDCS) which alters brain excitability, vision restoration can be potentiated in the chronic stage. Because it is possible that such therapy may be more effective during the early recovery phase after the stroke and can reach patients during the rehabilitation phase, investigators wished to explore the applicability, efficacy and safety of early intervention with a combined tDCS/VRT treatment.
Seven post-acute stroke homonymous hemianopia patients were assigned to 10 sessions of combined tDCS (2mA, 10 daily sessions of 15-20 min) and VRT. The primary outcome criterion was the pre-post change in perimetric detection thresholds in percent. The results were compared to 7 age and stroke lesion matched controls of our patient data pool who received standard rehabilitation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Posterior Cerebral Artery Stroke
- •Visual Field Defect
- •Lesion age 4 weeks up to 6 month max
排除标准
- •Electrical Implants
- •Metal artefacts in head
- •Visual Neglect
结局指标
主要结局
Change of mean sensitivity (in dB) detection threshold from baseline to post-intervention
时间窗: 14-20 days post treatment,
次要结局
未报告次要终点
研究者
Bernhard A. Sabel
Professor
University of Magdeburg
