Analgesic Efficacy of Adding Dexmedetomidine to Erector Spinae Plane Block Versus Subcostal Transverse Abdominis Plane Block in Laparoscopic Cholecystectomy
- Conditions
- Analgesic EfficacyDexmedetomidineErector Spinae Plane BlockSubcostal Transverse Abdominis Plane BlockLaparoscopic Cholecystectomy
- Registration Number
- NCT07075913
- Lead Sponsor
- Kafrelsheikh University
- Brief Summary
Our scientific work aimed to evaluate the analgesic efficacy of dexmedetomidine as an adjuvant to erector spinae plane block versus subcostal transverse abdominis plane block in patients undergoing laparoscopic cholecystectomy.
- Detailed Description
Laparoscopic cholecystectomy (LC) is the most commonly performed surgical procedure for the management of cholelithiasis. Acute pain after LC consists of somatic, parietal, and referred pain caused by trocar insertion, gall bladder resection, carbon dioxide insufflation, and other factors.
The subcostal transverse abdominis plane (SCTAP) block is the deposition of local anesthetic in the transverse abdominis plane inferior and parallel to the costal margin.
Ultrasound-guided erector spinae plane block (ESPB) is a popular, interfascial regional technique initially described for managing thoracic neuropathic pain.
Dexmedetomidine is an alpha-2 adrenergic receptor agonist that has been the focus of interest due to its sedative, analgesic, perioperative sympatholytic, and cardiovascular-stabilizing effects, resulting in reduced anesthetic requirements.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 40
- Age from 20 to 60 years.
- Both sexes.
- American Society of Anesthesiologists (ASA) physical status I and II.
- Patients were planned to undergo laparoscopic cholecystectomy.
- Patient's refusal to participate in the study.
- ASA III, IV.
- History of clinically significant cardiac, hepatic, renal, respiratory or neurological disease.
- Coagulopathy and bleeding disorders.
- Known allergy to any drug included in the study.
- Systemic or local infection at the puncture site.
- Body mass index (BMI) >35 (kg/m2).
- Failed technique.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Total dose of morphine consumption 24 hours postoperatively If the Visual analogue scale (VAS) is ≥ 3, IV morphine was given as a bolus of 2 mg (body weight \< or = 60 kg) or 3 mg (body weight \> 60 kg) with 5 minutes' lockout interval.
- Secondary Outcome Measures
Name Time Method Heart rate 24 hours postoperatively Heart rate was recorded at baseline, after injection then every 30 minutes till the end of surgery and after surgery at 0, 2, 4, 6, 8, 12, 16 and 24 h.
Mean arterial pressure 24 hours postoperatively Mean arterial pressure was recorded at baseline, after injection then every 30 minutes till the end of surgery and after surgery at 0, 2, 4, 6, 8, 12, 16 and 24 h.
Intraoperative opioid consumption Intraoperatively Intraoperative opioid consumption was recorded.
Time to first rescue analgesia 24 hours postoperatively Time to first rescue analgesia was recorded from the end of surgery till first dose of morphine administrated.
Degree of pain 24 hours postoperatively Visual analogue scale (VAS) was assessed after surgery at 0, 2, 4, 6, 8, 12, 16, 18, and 24 h \[where (0 = no pain and 10 = severe pain)\].
Incidence of complications 24 hours postoperatively Incidence of complications such as pneumothorax, local anesthetic systemic toxicity (LAST), bradycardia, hypotension, nausea, vomiting, and failed block were recorded.
Patient satisfaction 24 hours postoperatively Degree of patient satisfaction will be assessed on a 3-point scale; (1= Unsatisfied, 2= neither satisfied nor unsatisfied, 3= satisfied).
Trial Locations
- Locations (1)
Kafrelsheikh University
🇪🇬Kafr Ash Shaykh, Kafrelsheikh, Egypt
Kafrelsheikh University🇪🇬Kafr Ash Shaykh, Kafrelsheikh, Egypt