The role of mean systemic filling pressure and incubator tilt induced etCO2 change for the prediction of fluid responsiveness in neonates - a feasibility study

• Conditions: Hypovolemia; low volume; 10019280; 10028920

• Registration Number: NL-OMON38430
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

• Arterial catheter in place, well functioning with the tip positioned in the radial artery or posterior tibial artery (for Pmsf measurement)
• Mechanical ventilation with capnography (for ΔetCO2 assessment)
• Informed consent obtained from parents or representatives
• Steady state as judged by the attending physician

Exclusion Criteria

• Life-threatening congenital defects
• Perinatal asphyxia
• Intraventricular hemorrhage > grade 1
• Central venous catheter of peripheral infusion with administration of (cardiovascular) drugs, that can not be interrupted secondary to vascular occlusion for 30 seconds
• Condition in which an incubator tilt is contraindicated, such as for example external ventricular drainage;• Condition in which any handling is contraindicated

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The two study parameters are<br /><br>• The mean systemic filling pressure (Pmsf), assessed with an extremity<br /><br>occlusion test<br /><br>• The change in end-tidal carbon dioxide pressure (&Delta;etCO2) in response to a<br /><br>incubator tilting maneuver</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable</p><br>