Effects of Positive End-expiratory Pressure and Alveolar Recruitment on the Oxygenation and Respiratory Mechanics During One-lung Ventilation in the Supine Position
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 99
- 试验地点
- 2
- 主要终点
- PaO2, number of patients with hypoxia (PaO2< 90mmHg)
研究概览
简要总结
Hypoxia frequently develops during one lung ventilation in the supine position.The objective of this article is to study the impact of preemptive alveolar recruitment and subsequent positive end expiratory pressure on arterial oxygenation and lung mechanics during one lung ventilation in the supine position in patients undergoing thoracic surgery .
详细描述
outcome measures: respiratory parameters (Paw, Ppla, Compliance, Vd/Vt)and oxygenation parameters (PaO2, shunt fraction, Pa-AO2)
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- Double (Participant, Care Provider)
入排标准
- 年龄范围
- 20 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age: 20-75 years
排除标准
- •moderate to severe impaired respiratory function,
- •heart failure,
- •patients' refusal
研究组 & 干预措施
Control
zero PEEP
OLV strategy: PEEP
1. apply 8 cm H2O positive end expiratory pressure during one lung ventilation and until the end of surgery
干预措施: PEEP (Other)
OLV strategy: PEEP followed by AR
- alveolar recruitment strategy before one lung ventilation
- 8 cmH2O positive end expiratory pressure during one lung ventilation and until the end of surgery
干预措施: PEEP (Other)
结局指标
主要结局
PaO2, number of patients with hypoxia (PaO2< 90mmHg)
时间窗: participants will be followed for the duration of anesthesia, an expected average of 3 hours
blood samplings after induction of anesthesia, 15 and 30 min after OLV, after the 2nd TLV
次要结局
- intrapulmonary shunt(participants will be followed for the duration of anesthesia, an expected average of 3 hours)
研究者
Yongseon Choi
assistant professor
Yonsei University