Influence of Positive End-expiratory Pressure on the Cerebrovascular Autoregulation in Patients With Respiratory Failure
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Respiratory Insufficiency
- Sponsor
- Johannes Gutenberg University Mainz
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Integrity of the cerebrovascular autoregulation (CA)
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
The aim of the present study is to characterize the influence of an elevated positive end-expiratory pressure in patients with acute respiratory distress syndrome or acute lung injury on the cerebrovascular autoregulation.
Detailed Description
Cerebral blood flow velocity will be measured using transcranial Doppler sonography and then correlate with the invasive arterial blood pressure curve to calculate the index of cerebrovascular autoregulation Mx (Mx\>0.3 indicates impaired AR). The index of cerebrovascular autoregulation Mx was measured during baseline positive end-expiratory pressure (PEEP) levels and after lung recruitment with higher level of PEEP. The equality between this two PEEP levels was estimated and calculated with one side Wilcoxon test.
Investigators
Patrick Schramm
Senior Physician
Johannes Gutenberg University Mainz
Eligibility Criteria
Inclusion Criteria
- •respiratory failure
- •Age \>18 years
- •Invasive ventilation
Exclusion Criteria
- •preexisting cerebral illness
- •traumatic brain injury
- •meningitis or encephalitis
- •pregnancy
Outcomes
Primary Outcomes
Integrity of the cerebrovascular autoregulation (CA)
Time Frame: 30 Minutes
Cerebrovascular autoregulation will be calculated as a moving correlation index (Mx) from the cerebral blood flow velocity and the arterial blood pressure. It is a parameter without unit (index).