Influence Positive End-expiratory Pressure on Autoregulation in Patients With Respiratory Insufficiency
- Conditions
- Respiratory Insufficiency
- Interventions
- Procedure: positive end-expiratory pressure
- Registration Number
- NCT01376518
- Lead Sponsor
- Johannes Gutenberg University Mainz
- Brief Summary
The aim of the present study is to characterize the influence of an elevated positive end-expiratory pressure in patients with acute respiratory distress syndrome or acute lung injury on the cerebrovascular autoregulation.
- Detailed Description
Cerebral blood flow velocity will be measured using transcranial Doppler sonography and then correlate with the invasive arterial blood pressure curve to calculate the index of cerebrovascular autoregulation Mx (Mx\>0.3 indicates impaired AR). The index of cerebrovascular autoregulation Mx was measured during baseline positive end-expiratory pressure (PEEP) levels and after lung recruitment with higher level of PEEP. The equality between this two PEEP levels was estimated and calculated with one side Wilcoxon test.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 20
- respiratory failure
- Age >18 years
- Invasive ventilation
- Sepsis
- preexisting cerebral illness
- traumatic brain injury
- meningitis or encephalitis
- pregnancy
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description respiratory failure positive end-expiratory pressure patients with respiratory failure and need of high positive end-expiratory pressure ventilation.
- Primary Outcome Measures
Name Time Method Integrity of the cerebrovascular autoregulation (CA) 30 Minutes Cerebrovascular autoregulation will be calculated as a moving correlation index (Mx) from the cerebral blood flow velocity and the arterial blood pressure. It is a parameter without unit (index).
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University medical centre
🇩🇪Mainz, Germany