Impact of Moderate Positive End-expiratory Pressure on Hepatic Venous Flow in Patients Undergoing Cardiac Surgery

Konkuk University Medical Center0 sites15 target enrollmentMarch 2016

ConditionsValvular Heart Disease

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Valvular Heart Disease
Sponsor: Konkuk University Medical Center
Enrollment: 15
Primary Endpoint: forward hepatic venous flow
Last Updated: 10 years ago

Overview Investigators Eligibility Criteria Outcomes Similar Trials

Overview

Brief Summary

The purpose of this study is to determine the difference in the impact of moderate positive end-expiratory pressure (PEEP) on hepatic venous flow Doppler in patients undergoing cardiac surgery: conventional versus protective ventilation strategy The possible changes in forward and backward flows (Doppler profiles) of hepatic venous flow at different degrees of PEEP in conventional and protective ventilation strategies are analyzed by using intraoperative transesophageal echocardiography (TEE) in patients undergoing cardiac surgery .

Detailed Description

Following data would be determined after 5 min-exposure volume controlled ventilation employing tidal volume of 10 ml/kg and 6 ml/kg with low PEEP (with 2 mmHg) and moderate PEEP (7 mmHg) during remifentanil-based anesthesia (1.0 mcg/kg/min) for cardiac surgery (n=12) 1. sum of forward hepatic venous flow 2. sum of backward hepatic venous flow 3. peak velocity of diastolic hepatic venous flow 4. lung compliance 5. peak airway pressure 6. mean airway pressure 7. other pressure derived hemodynamic parameters:heart rate; systolic, diastolic, and mean blood pressures; systolic, diastolic, and mean pulmonary artery pressures; central venous pressure (CVP), pulmonary capillary

Registry

clinicaltrials.gov

Start Date

March 2016

End Date

May 2016

Last Updated

10 years ago

Study Type

Interventional

Study Design

Parallel