Impact of Moderate Positive End-expiratory Pressure on Hepatic Venous Flow in Patients Undergoing Cardiac Surgery
试验速览
- 阶段
- 不适用
- 入组人数
- 15
- 主要终点
- forward hepatic venous flow
研究概览
简要总结
The purpose of this study is to determine the difference in the impact of moderate positive end-expiratory pressure (PEEP) on hepatic venous flow Doppler in patients undergoing cardiac surgery: conventional versus protective ventilation strategy The possible changes in forward and backward flows (Doppler profiles) of hepatic venous flow at different degrees of PEEP in conventional and protective ventilation strategies are analyzed by using intraoperative transesophageal echocardiography (TEE) in patients undergoing cardiac surgery .
详细描述
Following data would be determined after 5 min-exposure volume controlled ventilation employing tidal volume of 10 ml/kg and 6 ml/kg with low PEEP (with 2 mmHg) and moderate PEEP (7 mmHg) during remifentanil-based anesthesia (1.0 mcg/kg/min) for cardiac surgery (n=12)
- sum of forward hepatic venous flow
- sum of backward hepatic venous flow
- peak velocity of diastolic hepatic venous flow
- lung compliance
- peak airway pressure
- mean airway pressure
- other pressure derived hemodynamic parameters:heart rate; systolic, diastolic, and mean blood pressures; systolic, diastolic, and mean pulmonary artery pressures; central venous pressure (CVP), pulmonary capillary
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 19 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing cardiac surgery
- •Patients provide written informed consents
排除标准
- •Re-do or tri-do surgery
- •Patients with active infection
- •Patients with endocrine disease
- •Patients ischemic heart disease
- •patients with tricuspid valve regurgitation greater than mild degree
结局指标
主要结局
forward hepatic venous flow
时间窗: 3 min after intervention
Hepatic venous flow Doppler, cm/sec, by transesophageal echocardiography
次要结局
- reversed hepatic venous flow(3 min after intervention)
研究者
Tae-Yop Kim, MD PhD
Professor of Anesthesiology
Konkuk University Medical Center