Comparison of Positive End Expiratory Pressure Titration Methods in ARDS Patients

Not Applicable

• Conditions: Acute Respiratory Distress Syndrome

• Registration Number: NCT03281473
• Lead Sponsor: University Hospital, Angers

Brief Summary

This study aims at assessing the short-term physiological effects of 2 positive end expiratory pressure titration strategies in patients with ARDS.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-07-11
• Study First Submitted QC: 2017-09-12
• Study First Posted: 2017-09-13
• Study Start: 2018-10-02
• Status Verified: 2019-03
• Last Update Submitted: 2019-03-19
• Last Update Posted: 2019-03-21
• Primary Completion: 2019-12
• Study Completion: 2019-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Age> 18 years
• Moderate or severe ARDS
• Consent to participation obtained from a relative

Exclusion Criteria

• Protect adult
• Pregnant or breastfeeding woman
• No-affiliation to the social security scheme
• Contra-indication to the placement of an esophageal pressure measuring catheter
• Pneumothorax
• Hemodynamic and / or respiratory instability
• Extra-corporeal membrane oxygenation

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Short-term effects of 2 PEEP titration strategies on gas exchange	2 hours 15 minutes

Secondary Outcome Measures

Name	Time	Method
Short-term effects of 2 PEEP titration strategies on hemodynamics	2 hours 15 min
Short-term effects of 2 PEEP titration strategies on respiratory mechanics	2 hours 15 min

Trial Locations

Locations (1)

University Hospital; 🇫🇷 Angers, France