Optimal PEEP in Pediatric Patients Under 17 Years of Age.

Not Applicable

Recruiting

• Conditions: Ventilation Therapy; Complications
• Interventions: Other: ventilation strategy

• Registration Number: NCT05726877
• Lead Sponsor: Seoul National University Hospital

Brief Summary

This study aimed to investigate the differences in positive end-expiratory pressure titration in the supine and prone positions by age in pediatric patients under 17 years of age who received general anesthesia and then evaluate the hemodynamic stability.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-10-17
• Status Verified: 2023-01
• Study First Submitted: 2023-01-06
• Study First Submitted QC: 2023-02-03
• Last Update Submitted: 2023-02-03
• Study First Posted: 2023-02-14
• Last Update Posted: 2023-02-14
• Primary Completion: 2023-12-31
• Study Completion: 2024-08-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 51

Inclusion Criteria

• patients who are scheduled to undergo general anesthesia in the prone position
• patients who are in age under 17 years

Exclusion Criteria

• had cyanosis or chronic respiratory failure
• had respiratory distress syndrome or bronchopulmonary dysplasia
• had laryngotracheal diseases
• had pulmonary hypertension
• receiving oxygen therapy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Experimental arm	ventilation strategy	All patients will be enrolled in the same arm.

Primary Outcome Measures

Name	Time	Method
Optimal positive end-expiratory pressure (PEEP)	60 minutes after prone positioning	result of decremental PEEP trial

Secondary Outcome Measures

Name	Time	Method
Impedance tidal variation	60 minutes after prone positioning	respiratory parameters measured by EIT device
overdistension or atelectasis	60 minutes after prone positioning	respiratory parameters measured by EIT device
regional ventilation delay	60 minutes after prone positioning	respiratory parameters measured by EIT device
arterial blood gas analysis, if patients has arterial catheter	10 minutes after intubation & 60 minutes after prone positioning	oxygen and cardon dioxide tension
end-expiratory lung impedance	60 minutes after prone positioning	respiratory parameters measured by EIT device
center of ventilation	60 minutes after prone positioning	respiratory parameters measured by EIT device
vital signs	60 minutes after prone positioning	heart rate (BPM)
end-expiratory lung volume	60 minutes after prone positioning	respiratory parameters measured by EIT device
regional respiratory system compliance	10 minutes after intubation	respiratory parameters measured by EIT device

Trial Locations

Locations (1)

Seoul National University Hospital; 🇰🇷 Seoul, Korea, Republic of