Comparison of Positive End Expiratory Pressure Titration Methods in ARDS Patients
Not Applicable
- Conditions
- Acute Respiratory Distress Syndrome
- Interventions
- Other: Strategy 1Other: Strategy 2
- Registration Number
- NCT03281473
- Lead Sponsor
- University Hospital, Angers
- Brief Summary
This study aims at assessing the short-term physiological effects of 2 positive end expiratory pressure titration strategies in patients with ARDS.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
- Age> 18 years
- Moderate or severe ARDS
- Consent to participation obtained from a relative
Exclusion Criteria
- Protect adult
- Pregnant or breastfeeding woman
- No-affiliation to the social security scheme
- Contra-indication to the placement of an esophageal pressure measuring catheter
- Pneumothorax
- Hemodynamic and / or respiratory instability
- Extra-corporeal membrane oxygenation
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Arms B Strategy 1 Strategy 2 - Washout period - Strategy 1 Arms A Strategy 1 Strategy 1 - Washout period - Strategy 2 Arms A Strategy 2 Strategy 1 - Washout period - Strategy 2 Arms B Strategy 2 Strategy 2 - Washout period - Strategy 1
- Primary Outcome Measures
Name Time Method Short-term effects of 2 PEEP titration strategies on gas exchange 2 hours 15 minutes
- Secondary Outcome Measures
Name Time Method Short-term effects of 2 PEEP titration strategies on hemodynamics 2 hours 15 min Short-term effects of 2 PEEP titration strategies on respiratory mechanics 2 hours 15 min
Trial Locations
- Locations (1)
University Hospital
đŸ‡«đŸ‡·Angers, France