Effects of Fructose and Exercise on Hepatic Lipid Metabolism

Not Applicable

Completed

• Conditions: Metabolism
• Interventions: Behavioral: weight maintenance, low sugar diet; Behavioral: weight maintenance, high fructose diet; Behavioral: weight maintenance, high fructose diet+ exercise

• Registration Number: NCT01121003
• Lead Sponsor: University of Lausanne

Brief Summary

8 healthy male volunteers will be studied each on 3 occasions, ie

* after 4 days on a weight maintenance diet containing 5% simple sugars + low physical activity

* after 4 days on a weight maintenance diet containing 30% fructose + low physical activity

* after 4 days on a weight maintenance diet containing 30% fructose + high physical activity At the end of each of these 3 periods, fructose induced hepatic de novo lipogenesis (13C palmitate synthesis in response to ingestion of a 13C fructose load) and plasma VLDL-triglyceride kinetics (measured with a bolus of 2H-labeled glycerol) will be measured

Detailed Description

Not available

Study Timeline

• Study Start: 2010-05
• Study First Submitted: 2010-05-06
• Study First Submitted QC: 2010-05-10
• Study First Posted: 2010-05-11
• Status Verified: 2011-10
• Primary Completion: 2011-10
• Study Completion: 2011-10
• Last Update Submitted: 2011-10-18
• Last Update Posted: 2011-10-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 8

Inclusion Criteria

• age between 18 and 30 years
• males
• BMI between 19 and 25
• low to moderate physical activity (< 3 sessions/week)

Exclusion Criteria

• smoking
• consumption of alcohol>50g/week
• consumption of drugs or illicit substances
• food allergies

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Low fructose diet/no exercise	weight maintenance, low sugar diet	-
high fructose diet/no exercise	weight maintenance, high fructose diet	-
high fructose diet+exercise	weight maintenance, high fructose diet+ exercise	-

Primary Outcome Measures

Name	Time	Method
Hepatic de novo lipogenesis	after 4 days on controlled diet+exercise	Measurement of 13C VLDL palmitate after ingestion of 13C fructose

Secondary Outcome Measures

Name	Time	Method
Plasma VLDL-triglyceride kinetics	after 4 days on controlled diet+exercise	Modelling of 2H5-glycerol incorporation in VLDL afetr administration of a bolus of 2H5 glycerol

Trial Locations

Locations (1)

Centre Hospitalier Universitaire Vaudois; 🇨🇭 Lausanne, VD, Switzerland