The effect of prolonged shivering thermogenesis on glucose homeostasis in overweight/obese humans

Completed

• Conditions: diabetes; type 2 diabetes; 10018424

• Registration Number: NL-OMON55206
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 52

Inclusion Criteria

In order to be eligible to participate in this study, a subject must meet all
of the following criteria:
- Signed informed consent
- Caucasian
- Healthy (as determined by dependent physician based on medical questionnaire
and ECG)
- Man, or postmenopausal (defined as at least 1year post cessation of menses)
woman
- Aged 40 - 75 years at the start of the study
- BMI between 27 and 35 kg/m2
- Stable dietary habits (no weight loss or gain >3kg in the past 3 months)

Exclusion Criteria

A potential subject who meets any of the following criteria will be excluded
from participation in this study:

- Not meeting all inclusion criteria
- Medication use known to hamper subject*s safety during study procedures
- Co-morbidities to which the intervention or program that may pose as a
complicating factor
- Subjects diagnosed with cardiovascular diseases or cancer
- Fasting plasma glucose * 7.0 mmol/l
- Haemoglobin < 7.8 mmol/l for women, < 8.4 mmol/L for men, unless ferritin >
20 ug/L
- Previously diagnosed with type 2 diabetes
- Abuse alcohol/drug abuse
- Subjects who do not want to be informed about unexpected medical findings
during the screening/study or do not wish that their physician is informed.
- Engagement in structured exercise > 2h per week
- Participation in another biomedical study within 1 month before the first
study
- Smoking
- Cold-acclimated, such as takes daily extended cold baths, works in a
refrigerated environment, or regular cold-water swimming within 1 month of
starting the study

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary study outcome of this study is area under the curve of the oral<br /><br>glucose tolerance test </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secondary outcome parameter of this study is skeletal muscle GLUT4<br /><br>translocation, as assessed by immunihistochemistry and wide-field microscopy</p><br>