CORRELATION OF SERUM LACTATES WITH PH, HB AND PAO2 IN PATIENT ADMITTED IN CRITICALCARE UNIT.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Negative correlation between lactate & pH, HCO3.
研究概览
简要总结
Critically ill patients often present with metabolic and respiratoryderangements. Serum lactate is a well-established marker of tissue hypoxiaand impaired cellular metabolism. Elevated lactate levels are associatedwith poor prognosis, multi-organ dysfunction, and increased mortality in ICU patients
AIM:To study the correlation between serum lactate levels and pH, hemoglobin, partial pressure of oxygen , partial pressure of carbon dioxide in patients admitted to the critical care unit.
OBJECTIVES:
-
To measure serum lactate levels in critically ill patients on admissionand during ICU stay.
-
To determine correlation between lactate and arterial pH.
-
To determine correlation between lactate and hemoglobinconcentration.
-
To determinerelation between c
SIGNIFICANCE OF THE STUDY:
Helps in understanding the pathophysiological relationships oflactate with ABG and Hb.
Provides prognostic insight in critically ill patients.
May improve early risk stratification and treatment decisions in ICU.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 99.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients admitted to ICU requiring ABG analysis.
- •Age more than 18 years.
- •Informed consent from patient/attendant.
排除标准
- •Chronic liver failure (affects lactate clearance).
- •Known inborn errors of metabolism.
- •Patients on metformin toxicity / cyanide poisoning.
结局指标
主要结局
Negative correlation between lactate & pH, HCO3.
时间窗: Baseline
Negative correlation between lactate & Hb.
时间窗: Baseline
Negative correlation between lactate & PaO2
时间窗: Baseline
Positive correlation between lactate & PaCO2 (in uncompensated states).
时间窗: Baseline
Higher lactate associated with increased ICU mortality.
时间窗: Baseline
次要结局
未报告次要终点
研究者
Dr. Akshaya N. Shetti
Pravara Institute Of Medical Sciences, Loni