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Clinical Trials/NL-OMON37260
NL-OMON37260
Recruiting
Not Applicable

Cognitive aging and neuroplasticity: prefrontal compensatory mechanisms during working-memory performance - fNIRS during working-memory performance in elderly

niversitair Medisch Centrum Sint Radboud0 sites66 target enrollmentTBD
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Conditionscognitieve verouderingmild cognitive impairmentmild memory loss

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
cognitieve veroudering
Sponsor
niversitair Medisch Centrum Sint Radboud
Enrollment
66
Status
Recruiting
Last Updated
2 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
TBD
End Date
TBD
Last Updated
2 years ago
Study Type
Interventional

Investigators

Sponsor
niversitair Medisch Centrum Sint Radboud

Eligibility Criteria

Inclusion Criteria

  • •\- Males and females aged 20\-35 (young adults group) or 60\-85 (older adults group and MCI group)
  • •\- MCI group: Diagnosis of amnestic Mild Cognitive Impairment according to International Working Group criteria.
  • •\- Right\-handed
  • •\- Dutch speaking
  • •\- Informed consent
  • •\- Normal or corrected\-to\-normal vision
  • •\- Access to a PC with internet connection at home (older adults group and MCI group)

Exclusion Criteria

  • •\- Estimated IQ \< 85 (based on Nederlandse Leestest voor Volwassenen (NLV) \-score)
  • •\- Mini\-Mental State Examination (MMSE) score of \< 27 (for healthy older adults group)
  • •\- Clinical Dementia Rating (CDR) \* 1 (i.e. fulfilling the criteria for diagnosis of dementia)
  • •\- Current psychiatric disorder, such as psychosis or major depression
  • •\- Current or past neurological disorder, such as severe cerebral vascular disease (e.g. cortical stroke, subarachnoid hemorrhage), Parkinson\*s disease, epilepsy, traumatic brain injury, central nervous system infection, brain tumor, and alcoholic encephalopathy. N.B. Transient Ischaemic Attack, lacunar infarction and white matter lesions are no exclusion criteria.
  • •\- Current severe systemic disease such as coronary artery disease, myocardial infarction \< 6 months, heart failure (unstable), chronic obstructive pulmonary disease (unstable)
  • •\- General medical conditions, such as repetitive strain injury (RSI), which may confound the results of the study, as judged by the investigator
  • •\- Blood pressure \> 160/90 mmHg (use of antihypertensives are allowed)
  • •\- Use of psychopharmacological drugs (anxiolytics, antidepressants, antipsychotic drugs, long\-acting benzodiazepines etc.)
  • •\- Current abuse of drugs or alcohol

Outcomes

Primary Outcomes

Not specified

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