The Optic Nerve Sheath Diameter for Prediction of Outcome After Cardiac Arrest: a Pilot Prospective Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 36
- 主要终点
- In-hospital mortality
研究概览
简要总结
Early prognostication in resuscitated cardiac arrest (CA) patients, within the first day after admission in the intensive care unit (ICU), remains difficult. Optic nerve sheath diameter (ONSD) measurement could predict increased intracranial pressure. Preliminary works showed that ONSD measurement could be used to predict outcome in post-CA patients.
The aim of this study was to assess the ability of bedside ONSD ultrasonographic measurement to predict survival and Cerebral Performance Category (CPC) score at hospital discharge in post-cardiac arrest patients treated with therapeutic hypothermia (TH).
详细描述
Prospective observational study including all consecutive successfully resuscitated and TH-treated CA patients without traumatic or neurological etiology of CA in two French ICUs. ONSD measurements were performed on day 1, 2, and 3 after return of spontaneous circulation (ONSD1,2,3 respectively).
The primary outcome is survival at hospital discharge (with an average follow-up of 3 month until ICU admission).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Unconscious (Glasgow Coma Scale ≤6)
- •≥18 years old
- •Admitted in ICU after successful resuscitation from CA
- •Treated with TH targeted to 33°C
排除标准
- •unavailable ONSD measurement within 24 hours after return of spontaneous circulation (unavailable investigator, early death, or major hemodynamic instability)
- •Traumatic or neurological origin of CA
- •Previous cerebrovascular disease
- •Facial trauma affecting the orbits and/or eyeballs
- •Previous history of ocular pathology such as exophthalmia, glaucoma or cataract.
结局指标
主要结局
In-hospital mortality
时间窗: 3 months
participants will be followed for the duration of hospital stay, an expected average of 3 months.
次要结局
未报告次要终点
研究者
Chelly Jonathan
MD
Hopital of Melun