Effects of short-term energy restriction on liver lipids

Not Applicable

Completed

• Conditions: Hepatology, Surgery; Surgery

• Registration Number: ISRCTN65605485
• Lead Sponsor: niversity of Nottingham (UK)

Brief Summary

2017 results in: https://www.ncbi.nlm.nih.gov/pubmed/28230324

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-05-17
• Study Completion: 2014-09-30
• Last Update Posted: 20 August 2018

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

1. Patients accepted for weight loss surgery at Derby Hospitals NHS Foundation Trust
2. Male and female participants
3. Lower age limit = 18 years, no upper age limit

Exclusion Criteria

1. Secondary NAFLD
2. Diabetes mellitus treated by insulin, GLP1 or pioglitazone
3. Excess alcohol intake (exceeding national recommendations)
4. Patients receiving anti-inflammatory medication
5. Pregnancy and lactation
6. Any other condition judged by the investigative team to be clinically significant
Exclusions recommended by LighterLife (meal replacement plan):
7.1. Some cardiac conditions (including heart failure, arrhythmias, valve disease, requiring treatment)
7.2. Some cerebrovascular conditions. (Patients who have suffered cerebrovascular disease may participate if the following conditions are met; more than six months has passed and the patient?s condition is stable)
7.3. Schizophrenia, delusional and bipolar disorder, psychosis
7.4. Epilepsy or history of seizure
7.5. Kidney or liver disease (severe)
7.6. Total lactose intolerance
7.7. Type 1 diabetes
7.8. Anorexia or bulimia or other eating disorder undergoing or awaiting treatment.
7.9. Porphyria
7.10. Taking prescribed anticoagulants, digoxin, lithium or monoamine oxidase inhibitors (MAOIs)
7.11. Unstable angina
7.12. Major depressive disorder

Study & Design

• Study Type: Interventional
• Study Design: Not specified