Effect of 24 h Severe Energy Restriction on Appetite Regulation and Ad-libitum Energy Intake

Not Applicable

Completed

• Conditions: Deficiency; Calorie
• Interventions: Other: Energy intake

• Registration Number: NCT02696772
• Lead Sponsor: Loughborough University

Brief Summary

Long term maintenance of weight loss is generally poor, which is at least partly due to increased feelings of hunger associated with restricting what can be eaten. Intermittent severe energy restriction is a novel dietary strategy that requires individuals to consume a very-low energy diet for 1-4 days per week, allowing normal feeding patterns to be adopted on the other days in the week. However, the effect of a consuming a very-low energy diet on appetite regulation, which might represent a key marker of long-term adherence to dieting, has not been determined. This study aimed to assess the effects of severely restricting energy intake for 24 h on markers of appetite regulation, energy balance and metabolism compared to an adequate energy trial.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-10
• Primary Completion: 2015-06
• Study Completion: 2015-09
• Study First Submitted: 2016-02-26
• Study First Submitted QC: 2016-02-26
• Status Verified: 2016-03
• Last Update Submitted: 2016-03-01
• Study First Posted: 2016-03-02
• Last Update Posted: 2016-03-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 18

Inclusion Criteria

• non-smoker, not currently dieting, weight stable for >6 months (self-reported), no known history of cardiovascular or renal disease.

Exclusion Criteria

• food allergies, dislike or intolerance of study foods and drinks, irregular eating patterns, use of medication that could influence hormone concentrations, excessive alcohol consumption (>4 units/day), intensive training schedule (>10 h/week)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Energy restriction	Energy intake	Intervention day diet containing 25% of estimated energy requirements
Energy balance	Energy intake	Intervention day diet containing 100% of estimated energy requirements

Primary Outcome Measures

Name	Time	Method
Ad-libitum energy intake	48 hours	Measured at laboratory-based meals and weight food records
Plasma acylated Ghrelin	24 hours	Measured using ELISA from venous blood samples
Plasma active glugagon-like peptide 1	24 hours	Measured using ELISA from venous blood samples
Subjective appetite	48 hours	Measured using visual analogue scales

Secondary Outcome Measures

Name	Time	Method
Plasma glucose	24 hours	Measured using colorimetric assay from venous blood samples
Fat oxidation	24 hours	Measured under resting conditions using indirect calorimetry
carbohydrate oxidation	24 hors	Measured under resting conditions using indirect calorimetry
Plasma Non-esterified Fatty acids	24 hours	Measured using colorimetric from venous blood samples
Plasma insulin	24 hours	Measured using ELISA from venous blood samples
Energy expenditure	24 hours	Measured under resting conditions using indirect calorimetry